Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle

[Display omitted] To evaluate the feasibility of producing solid dispersions with 3-fluid nozzle spray drying to improve the dissolution behavior of lipophilic drugs, 60 experiments were performed based on a Design of Experiment. Solid dispersions with mannitol as a hydrophilic matrix and diazepam a...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2018-02, Vol.123, p.50-58
Hauptverfasser:	Kauppinen, Ari, Broekhuis, Joep, Grasmeijer, Niels, Tonnis, Wouter, Ketolainen, Jarkko, Frijlink, Henderik W., Hinrichs, Wouter L.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Fluid nozzle Design of experiments Diazepam - chemistry Dissolution rate Drug Carriers - chemistry Drug Compounding - methods Hydrophobic and Hydrophilic Interactions Lipophilic drug Mannitol - chemistry Particle Size Poor water solubility Solid dispersion Solubility Solutions - chemistry Solvents - chemistry Spray drying Water - chemistry Yield
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