Designing a mutant Candida uricase with improved polymerization state and enzymatic activity

Abstract As human uricase has been silenced during evolution, counterparts from other species become an alternative for the treatment of hyperuricemia. Candida uricase is a promising option among them, but its aggregation propensity remains a major obstacle to clinical use. In this study, we designe...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2017-11, Vol.30 (11), p.753-759
Hauptverfasser:	Tao, Lei, Li, Dandan, Li, Yonghong, Shi, Xinchang, Wang, Junzhi, Rao, Chunming, Zhang, Yingqi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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