Interstitial Nephritis Secondary to Vedolizumab Treatment in Crohn Disease and Safe Rechallenge Using Steroids: A Case Report

Vedolizumab is a gut-selective humanized monoclonal antibody that binds selectively to the α4 β7 integrin and acts as a lymphocyte-homing antagonist. It is indicated in ulcerative colitis and Crohn disease. We report a case of acute interstitial nephritis following vedolizumab infusion in a 55-year-...

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Veröffentlicht in:	American journal of kidney diseases 2018-01, Vol.71 (1), p.142-145
Hauptverfasser:	Bailly, Elodie, Von Tokarski, Florent, Beau-Salinas, Frédérique, Picon, Laurence, Miquelestorena-Standley, Elodie, Rousseau, Geoffroy, Jonville-Bera, Annie-Pierre, Halimi, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	acute interstitial nephritis (AIN) acute kidney injury (AKI) acute renal failure (ARF) Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects case report Crohn Disease - drug therapy Crohn Disease - metabolism Crohn’s disease Drug Hypersensitivity Female Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - adverse effects glucocorticoids Glucocorticoids - administration & dosage Humans Inflammatory bowel disease (IBD) Infusions, Intravenous Integrins - antagonists & inhibitors kidney biopsy Kidney Function Tests - methods Middle Aged monoclonal antibody Nephritis, Interstitial - chemically induced Nephritis, Interstitial - diagnosis Nephritis, Interstitial - immunology Nephritis, Interstitial - therapy Recovery of Function Treatment Outcome ulcerative colitis vedolizumab
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