Structure and function of a novel antioxidant peptide from the skin of tropical frogs

The amphibian skin plays an important role protecting the organism from external harmful factors such as microorganisms or UV radiation. Based on biorational strategies, many studies have investigated the cutaneous secretion of anurans as a source of bioactive molecules. By a peptidomic approach, a...

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Veröffentlicht in:	Free radical biology & medicine 2018-02, Vol.115, p.68-79
Hauptverfasser:	Barbosa, Eder Alves, Oliveira, Ana, Plácido, Alexandra, Socodato, Renato, Portugal, Camila C., Mafud, Ana Carolina, Ombredane, Alicia S., Moreira, Daniel C., Vale, Nuno, Bessa, Lucinda J., Joanitti, Graziella A., Alves, Cláudia, Gomes, Paula, Delerue-Matos, Cristina, Mascarenhas, Yvonne Primerano, Marani, Mariela M., Relvas, João B., Pintado, Manuela, Leite, José Roberto S.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibia Amphibian Proteins - genetics Amphibian Proteins - immunology Amphibian Proteins - metabolism Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Antimicrobial Cationic Peptides - metabolism Antioxidant peptide Antioxidants - metabolism Antioxidin Anura - physiology Bacterial Infections - immunology Cloning, Molecular Fibroblasts - physiology Free Radical Scavengers - metabolism Mice Microglia Microglia - metabolism Molecular Structure Neuroprotection NIH 3T3 Cells Oxidation-Reduction Protein Conformation Reactive oxygen species Reactive Oxygen Species - metabolism Skin - metabolism Skin secretion
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