NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis

Reactive oxygen species (ROS) produced by NADPH phagocyte oxidase isoform (NOX2) are critical for the elimination of intracellular pathogens in many infections. Despite their importance, the role of ROS following infection with the eukaryotic pathogen has not been fully elucidated. We addressed the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2018-01, Vol.200 (1), p.196-208
Hauptverfasser:	Carneiro, Matheus B H, Roma, Eric H, Ranson, Adam J, Doria, Nicole A, Debrabant, Alain, Sacks, David L, Vieira, Leda Q, Peters, Nathan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis CD4 antigen CD95 antigen Cell Movement Cells, Cultured Chronic infection CYBB protein fas Receptor - metabolism Female Hydrogen peroxide Infections Inflammation Inflammation - immunology Leishmania - immunology Leishmania amazonensis Leishmaniasis - immunology Leukocytes (neutrophilic) Lymphocytes T Male Mice Mice, Inbred C57BL Mice, Knockout NAD(P)H oxidase NADPH Oxidase 2 - genetics NADPH Oxidase 2 - metabolism Neutrophils Neutrophils - immunology Parasite Load Pathogens Pathology Phenotypes Reactive oxygen species Reactive Oxygen Species - metabolism Skin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!