Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple...
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| Veröffentlicht in: | The Journal of immunology (1950) 2017-12, Vol.199 (11), p.3721-3730 |
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| container_title | The Journal of immunology (1950) |
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| creator | Sundblad, Victoria Morosi, Luciano G Geffner, Jorge R Rabinovich, Gabriel A |
| description | Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. Therapeutic strategies aimed at targeting Gal-1-glycan interactions will contribute to overcome cancer immunosuppression and reinforce antimicrobial immunity, whereas stimulation of Gal-1-driven immunoregulatory circuits will help to mitigate exuberant inflammation. |
| doi_str_mv | 10.4049/jimmunol.1701172 |
| format | Article |
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Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. 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Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. Therapeutic strategies aimed at targeting Gal-1-glycan interactions will contribute to overcome cancer immunosuppression and reinforce antimicrobial immunity, whereas stimulation of Gal-1-driven immunoregulatory circuits will help to mitigate exuberant inflammation.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - immunology</subject><subject>Cancer</subject><subject>Cell Movement</subject><subject>Cell survival</subject><subject>Chronic Disease</subject><subject>Compartments</subject><subject>Cytokines</subject><subject>Degranulation</subject><subject>Female</subject><subject>Galectin 1 - immunology</subject><subject>Galectin-1</subject><subject>Glycan</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity - immunology</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Immunoregulation</subject><subject>Immunosuppression</subject><subject>Infection - immunology</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Leukocyte migration</subject><subject>Leukocytes (eosinophilic)</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy - immunology</subject><subject>Proteins</subject><subject>Receptor density</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMFLwzAchYMobk7vniTgxUvmL2mSNt7G0DkZCDLPJU1T1pkms2kP_vd2bPPg6V2-93h8CN1SmHLg6nFbN03vg5vSFChN2RkaUyGASAnyHI0BGCM0lekIXcW4BQAJjF-iEVNUZAnPxmi90M6arvaEPuEZftPmi4SKzJwj61aXNuLa425j8YeNwfVdHTwOFZ6ZvrNY-xLPN23wtcFLXzndNHpPXKOLSrtob445QZ8vz-v5K1m9L5bz2YoYnoiOVFyXQtlEF0aBoIJmUGoqdVpQXiaZ4aBZWlS6kKYUhYTMVIkRFEzBBVeMJxP0cNjdteG7t7HLmzoa65z2NvQxp0pKpRRjakDv_6Hb0Ld-eDdQGU8GSUAHCg6UaUOMra3yXVs3uv3JKeR74_nJeH40PlTujsN90djyr3BSnPwCnbJ8NQ</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Sundblad, Victoria</creator><creator>Morosi, Luciano G</creator><creator>Geffner, Jorge R</creator><creator>Rabinovich, Gabriel A</creator><general>American Association of Immunologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4649-6473</orcidid><orcidid>https://orcid.org/0000-0002-7011-6821</orcidid></search><sort><creationdate>20171201</creationdate><title>Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation</title><author>Sundblad, Victoria ; 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Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. 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| subjects | Acute Disease Animals Autoimmune diseases Autoimmune Diseases - immunology Cancer Cell Movement Cell survival Chronic Disease Compartments Cytokines Degranulation Female Galectin 1 - immunology Galectin-1 Glycan Humans Hypersensitivity Hypersensitivity - immunology Immunology Immunomodulation Immunoregulation Immunosuppression Infection - immunology Inflammation Inflammation - immunology Leukocyte migration Leukocytes (eosinophilic) Lymphocytes B Lymphocytes T Molecular Targeted Therapy Neoplasms - immunology Pregnancy Pregnancy - immunology Proteins Receptor density |
| title | Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation |
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