Cost-utility of empagliflozin in patients with type 2 diabetes at high cardiovascular risk
In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard...
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Veröffentlicht in: | Journal of diabetes and its complications 2018-02, Vol.32 (2), p.210-215 |
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Sprache: | eng |
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Zusammenfassung: | In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for the prevention of cardiovascular morbidity and mortality in patients with T2D.
A Markov model was developed to assess the cost-effectiveness of empagliflozin (versus standard treatment) for the prevention of cardiovascular morbidity and mortality in patients with T2D using a 3-month cycle length and a lifetime horizon. Data sources included the EMPA-REG randomized clinical trial and other published epidemiological studies. Outcomes included treatment costs (in 2016 US$), quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs). Probabilistic sensitivity analysis (PSA) was performed to test the robustness of conclusions.
Empagliflozin use resulted in higher total lifetime treatment costs ($371,450 versus $272,966) but yielded greater QALYs (10.712 vs. 9.419) compared to standard treatment. This corresponded to an ICER of $76,167 per QALY gained. PSA suggested empagliflozin would be cost-effective in 96% of 10,000 iterations assuming a willingness-to-pay threshold of $100,000 per QALY gained.
Empagliflozin may be cost-effective compared to standard treatment in T2D patients at high cardiovascular risk.
•Empagliflozin use resulted in higher lifetime treatment costs vs. standard treatment.•Empagliflozin use resulted in more quality adjusted life years (QALY) vs. standard treatment.•Empagliflozin was cost-effective vs. standard treatment, assuming a WTP threshold of $100,000/QALY. |
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ISSN: | 1056-8727 1873-460X |
DOI: | 10.1016/j.jdiacomp.2017.10.006 |