CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231

Claudin-6 (CLDN6), a critical tight junction protein acting as a tumor suppressor in breast cancer, is also considered to be a stem cell marker. Triple-negative breast cancer (TNBC) is a subtype of claudin-low and stem cell-like breast cancer which is chemoresistant to multiple anti-cancer drugs. Th...

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Veröffentlicht in:	Molecular and cellular biochemistry 2018-06, Vol.443 (1-2), p.169-180
Hauptverfasser:	Yang, Minlan, Li, Yanru, Ruan, Yang, Lu, Yan, Lin, Dongjing, Xie, Yinping, Dong, Bing, Dang, Qihua, Quan, Chengshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Cancer Cancer treatment Cardiology Cell Line, Tumor Chemoresistance Chemotherapy Claudins - genetics Claudins - metabolism Doxorubicin - pharmacology Drug resistance Drug Resistance, Neoplasm E-cadherin Extracellular signal-regulated kinase Female Humans Kinesin - genetics Kinesin - metabolism Life Sciences MAP Kinase Signaling System - drug effects Markers Medical Biochemistry Mesenchyme Myosins - genetics Myosins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oct-4 protein Oncology Senescence Signal transduction Signaling Stem cells Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumor suppressor genes Vimentin
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