Synthesis and Characterization of Ultralow Fouling Poly(N‑acryloyl-glycinamide) Brushes

Synthesis and Characterization of Ultralow Fouling Poly(N‑acryloyl-glycinamide) Brushes

The rational design of biomaterials with antifouling properties still remains a challenge, although this is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein, we synthesized and characterized poly­(N-acryloylglycinamide) (po...

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Veröffentlicht in:Langmuir 2017-12, Vol.33 (49), p.13964-13972
Hauptverfasser: Yang, Fengyu, Liu, Yonglan, Zhang, Yanxian, Ren, Baiping, Xu, Jianxiong, Zheng, Jie
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container_end_page 13972
container_issue 49
container_start_page 13964
container_title Langmuir
container_volume 33
creator Yang, Fengyu
Liu, Yonglan
Zhang, Yanxian
Ren, Baiping
Xu, Jianxiong
Zheng, Jie
description The rational design of biomaterials with antifouling properties still remains a challenge, although this is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein, we synthesized and characterized poly­(N-acryloylglycinamide) (polyNAGA) and then grafted poly­(NAGA) onto Au substrate to form polymer brushes with well-controlled film stability, wettability, and thickness using surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to its antifouling property. The antifouling performances of poly­(NAGA) brushes of different film thicknesses were then rigorously assessed and compared using protein adsorption assay from undiluted blood serum and plasma, cell-adhesive assay, and bacterial assay. The resulting poly­(NAGA) brushes with a film thickness of 25–35 nm exhibited excellent in vitro antifouling ability to prevent unwanted protein adsorption (
doi_str_mv 10.1021/acs.langmuir.7b03435
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