Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS

Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression. However, little is known about the metabolomic changes in the hypothalamus...

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Veröffentlicht in:	Molecular bioSystems 2017, Vol.13 (12), p.2715-2728
Hauptverfasser:	Wu, Yu, Li, Yonghong, Jia, Yanjuan, Wei, Chaojun, Xu, Hui, Guo, Rui, Li, Yuanting, Jia, Jing, Qi, Xiaoming, Gao, Xiaoling
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Amino acids Amino Acids - metabolism Animals Body Weight Depression - etiology Depression - immunology Depression - metabolism Gas chromatography Gas Chromatography-Mass Spectrometry - methods Hypothalamus Hypothalamus - metabolism Inflammation Inflammation - complications Inflammation - immunology Inflammation - metabolism Lipopolysaccharides Male Mass spectrometry Mass spectroscopy Mental depression Metabolism Metabolites Metabolomics Mice Multivariate analysis Neurotransmitters Open-field behavior Pathogenesis Patients Purines - metabolism Statistical analysis Sucrose Sugar Swimming
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