Statins, neuromuscular degenerative disease and an amyotrophic lateral sclerosis-like syndrome : An analysis of individual case safety reports from vigibase

The WHO Foundation Collaborating Centre for International Drug Monitoring (Uppsala Monitoring Centre [UMC]) has received many individual case safety reports (ICSRs) associating HMG-CoA reductase inhibitor drug (statin) use with the occurrence of muscle damage, including rhabdomyolysis, and also peri...

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Veröffentlicht in:	Drug safety 2007-01, Vol.30 (6), p.515-525
Hauptverfasser:	EDWARDS, I. Ralph, STAR, Kristina, KIURU, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse Drug Reaction Reporting Systems Aged Aged, 80 and over Amyotrophic Lateral Sclerosis - chemically induced Amyotrophic Lateral Sclerosis - diagnosis Anticholesteremic Agents - adverse effects Biological and medical sciences Causality Cerebrospinal fluid. Meninges. Spinal cord Databases, Factual Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diseases of striated muscles. Neuromuscular diseases Female General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Male Medical sciences Middle Aged Motor Neuron Disease - chemically induced Motor Neuron Disease - diagnosis Nervous system (semeiology, syndromes) Neurology Pharmacology. Drug treatments Retrospective Studies Syndrome
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