The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV

Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors. Using a cell-...

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Veröffentlicht in:	Mutagenesis 2007-05, Vol.22 (3), p.217-233
Hauptverfasser:	Kuhfittig-Kulle, Steffi, Feldmann, Elke, Odersky, Andrea, Kuliczkowska, Aneta, Goedecke, Wolfgang, Eggert, Angelika, Pfeiffer, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - genetics Biological and medical sciences Blotting, Western Cell Extracts CHO Cells Cloning, Molecular Cricetinae Cricetulus DNA Breaks, Double-Stranded DNA Repair - genetics DNA Repair - physiology DNA Repair Enzymes - deficiency DNA Repair Enzymes - genetics DNA-Activated Protein Kinase - deficiency DNA-Activated Protein Kinase - genetics DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology Immunohistochemistry Kinetics Ku Autoantigen Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagenicity Tests - methods Oligonucleotides - genetics
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