MicroRNA-30a-3p is overexpressed in the placentas of patients with preeclampsia and affects trophoblast invasion and apoptosis by its effects on IGF-1

Preeclampsia (PE) affects many women globally and remains a primary cause of neonatal and maternal morbidity and mortality. Aberrant placental microRNA (miRNA) expression might be associated with PE. Previously, 33 PE-related miRNAs, 11 up-regulated and 23 down-regulated, were detected in placentas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of obstetrics and gynecology 2018-02, Vol.218 (2), p.249.e1-249.e12
Hauptverfasser:	Niu, Zi-ru, Han, Tao, Sun, Xiao-luan, Luan, Li-xia, Gou, Wen-li, Zhu, Xiao-ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult apoptosis Apoptosis - genetics Biomarkers - metabolism Blotting, Western Case-Control Studies Cells, Cultured Epigenesis, Genetic epigenetics Female functional assays Gene Expression Regulation, Developmental Humans IGF-1 Insulin-Like Growth Factor I - metabolism invasion microRNA MicroRNAs - metabolism placenta Placenta - metabolism Pre-Eclampsia - genetics Pre-Eclampsia - metabolism preeclampsia Pregnancy Reverse Transcriptase Polymerase Chain Reaction trophoblast Trophoblasts - physiology Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!