Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study
With the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action. The primary objective of this study was to gain an understanding of how a new formulation technolo...
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| Veröffentlicht in: | British journal of nutrition 2017-11, Vol.118 (10), p.813-821 |
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| creator | Marriage, Barbara J. Williams, Jennifer A. Choe, Yong S. Maki, Kevin C. Vurma, Mustafa DeMichele, Stephen J. |
| description | With the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action. The primary objective of this study was to gain an understanding of how a new formulation technology (mixture of mono- and diglycerides (MDG)), affected lutein absorption. Subjects (n 24) were randomised in a cross-over, double-blind study to receive a single dose of 6 mg lutein (FloraGLO 20 %) provided as capsules containing either high-oleic safflower (SAF) oil or a MDG oil. Subjects receiving a single dose of lutein in MDG showed a significantly greater change from baseline (0 h) to 4, 6, 8, 12, 24, 48 and 336 h (P |
| doi_str_mv | 10.1017/S0007114517002963 |
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The primary objective of this study was to gain an understanding of how a new formulation technology (mixture of mono- and diglycerides (MDG)), affected lutein absorption. Subjects (n 24) were randomised in a cross-over, double-blind study to receive a single dose of 6 mg lutein (FloraGLO 20 %) provided as capsules containing either high-oleic safflower (SAF) oil or a MDG oil. Subjects receiving a single dose of lutein in MDG showed a significantly greater change from baseline (0 h) to 4, 6, 8, 12, 24, 48 and 336 h (P<0·05) and baseline adjusted AUC for plasma lutein at 48 and 336 h (P<0·001) as compared with subjects given lutein in SAF. Analysis of the 48 h absorption kinetics of lutein showed that the time to peak level of lutein (12 h) was the same for SAF and MDG groups, but the change in plasma lutein at 12 and 48 h were 129 and 320 % higher, respectively, for MDG compared with SAF. This difference continued as the adjusted AUC 0–48 and 0–336 h for the MDG group was 232 and 900 % higher, respectively, v. SAF. The study data show that by changing the lipid that is combined with a lutein supplement results in significant increases in lutein absorption in healthy adults.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114517002963</identifier><identifier>PMID: 29151374</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Absorption ; Adult ; Adults ; Area Under Curve ; Bioavailability ; Carotenoids ; Cataracts ; Chronic illnesses ; Chronic infection ; Cross-Over Studies ; Diet ; Dietary intake ; Dietary Supplements ; Diglycerides ; Diglycerides - pharmacology ; Double-Blind Method ; Double-blind studies ; Female ; Fistula ; Human and Clinical Nutrition ; Humans ; Intestinal Absorption ; Lipids ; Lutein ; Lutein - blood ; Lutein - pharmacokinetics ; Macular degeneration ; Male ; Monoglycerides ; Monoglycerides - pharmacology ; Nutrition research ; Oils & fats ; Oleic Acid - pharmacology ; Physiological effects ; R&D ; Randomization ; Reference Values ; Research & development ; Safflower Oil ; Triglycerides - pharmacology ; Xanthophylls</subject><ispartof>British journal of nutrition, 2017-11, Vol.118 (10), p.813-821</ispartof><rights>Copyright © The Authors 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-83d34c1e1f774365beb60bd664087015bf7e948344a6a759fba4a5af121794843</citedby><cites>FETCH-LOGICAL-c416t-83d34c1e1f774365beb60bd664087015bf7e948344a6a759fba4a5af121794843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114517002963/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55607</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29151374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marriage, Barbara J.</creatorcontrib><creatorcontrib>Williams, Jennifer A.</creatorcontrib><creatorcontrib>Choe, Yong S.</creatorcontrib><creatorcontrib>Maki, Kevin C.</creatorcontrib><creatorcontrib>Vurma, Mustafa</creatorcontrib><creatorcontrib>DeMichele, Stephen J.</creatorcontrib><title>Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>With the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action. The primary objective of this study was to gain an understanding of how a new formulation technology (mixture of mono- and diglycerides (MDG)), affected lutein absorption. Subjects (n 24) were randomised in a cross-over, double-blind study to receive a single dose of 6 mg lutein (FloraGLO 20 %) provided as capsules containing either high-oleic safflower (SAF) oil or a MDG oil. Subjects receiving a single dose of lutein in MDG showed a significantly greater change from baseline (0 h) to 4, 6, 8, 12, 24, 48 and 336 h (P<0·05) and baseline adjusted AUC for plasma lutein at 48 and 336 h (P<0·001) as compared with subjects given lutein in SAF. Analysis of the 48 h absorption kinetics of lutein showed that the time to peak level of lutein (12 h) was the same for SAF and MDG groups, but the change in plasma lutein at 12 and 48 h were 129 and 320 % higher, respectively, for MDG compared with SAF. This difference continued as the adjusted AUC 0–48 and 0–336 h for the MDG group was 232 and 900 % higher, respectively, v. SAF. The study data show that by changing the lipid that is combined with a lutein supplement results in significant increases in lutein absorption in healthy adults.</description><subject>Absorption</subject><subject>Adult</subject><subject>Adults</subject><subject>Area Under Curve</subject><subject>Bioavailability</subject><subject>Carotenoids</subject><subject>Cataracts</subject><subject>Chronic illnesses</subject><subject>Chronic infection</subject><subject>Cross-Over Studies</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Dietary Supplements</subject><subject>Diglycerides</subject><subject>Diglycerides - pharmacology</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Female</subject><subject>Fistula</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Lipids</subject><subject>Lutein</subject><subject>Lutein - blood</subject><subject>Lutein - pharmacokinetics</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Monoglycerides</subject><subject>Monoglycerides - pharmacology</subject><subject>Nutrition research</subject><subject>Oils & fats</subject><subject>Oleic Acid - pharmacology</subject><subject>Physiological effects</subject><subject>R&D</subject><subject>Randomization</subject><subject>Reference Values</subject><subject>Research & development</subject><subject>Safflower Oil</subject><subject>Triglycerides - pharmacology</subject><subject>Xanthophylls</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU9v1DAQxa0KRJfCB-gFWeqFQwOe2LE3vVUV_6QiDsA5suPJ1pUTL3ZSaQ98d2bpUlUgTtb4vfnNjB5jpyDegADz9qsQwgCoBowQdavlEVuBMk1Va10_Yau9XO31Y_a8lFsq1yDaZ-y4bqEBadSK_fycplRxO3nuwybueszBY-Fh3OZ0hzwuM4aJW1dS3s4hTZyqG7Rxvtlx65c4lwtueSZAGkNBf859WlzEysUwUdXnVEpFqHzOS5g2pPhUkJd58bsX7OlgY8GXh_eEfX__7tvVx-r6y4dPV5fXVa9Az9Vaeql6QBiMUVI3Dp0WzmutxNoIaNxgsFVrqZTV1jTt4KyyjR2gBkP_Sp6w1_dcOurHgmXuaNceY7QTpqV00BJLaSNrsp79Zb1NS55oO3IZIQmnGnLBvev3eRmHbpvDaPOuA9Hts-n-yYZ6Xh3IixvRP3T8CYMM8gC1o6MYNvho9n-xvwAsx5hI</recordid><startdate>20171128</startdate><enddate>20171128</enddate><creator>Marriage, Barbara J.</creator><creator>Williams, Jennifer A.</creator><creator>Choe, Yong S.</creator><creator>Maki, Kevin C.</creator><creator>Vurma, Mustafa</creator><creator>DeMichele, Stephen J.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171128</creationdate><title>Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study</title><author>Marriage, Barbara J. ; Williams, Jennifer A. ; Choe, Yong S. ; Maki, Kevin C. ; Vurma, Mustafa ; DeMichele, Stephen J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-83d34c1e1f774365beb60bd664087015bf7e948344a6a759fba4a5af121794843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorption</topic><topic>Adult</topic><topic>Adults</topic><topic>Area Under Curve</topic><topic>Bioavailability</topic><topic>Carotenoids</topic><topic>Cataracts</topic><topic>Chronic illnesses</topic><topic>Chronic infection</topic><topic>Cross-Over Studies</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Dietary Supplements</topic><topic>Diglycerides</topic><topic>Diglycerides - pharmacology</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Female</topic><topic>Fistula</topic><topic>Human and Clinical Nutrition</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Lipids</topic><topic>Lutein</topic><topic>Lutein - blood</topic><topic>Lutein - pharmacokinetics</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Monoglycerides</topic><topic>Monoglycerides - pharmacology</topic><topic>Nutrition research</topic><topic>Oils & fats</topic><topic>Oleic Acid - pharmacology</topic><topic>Physiological effects</topic><topic>R&D</topic><topic>Randomization</topic><topic>Reference Values</topic><topic>Research & development</topic><topic>Safflower Oil</topic><topic>Triglycerides - pharmacology</topic><topic>Xanthophylls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marriage, Barbara J.</creatorcontrib><creatorcontrib>Williams, Jennifer A.</creatorcontrib><creatorcontrib>Choe, Yong S.</creatorcontrib><creatorcontrib>Maki, Kevin C.</creatorcontrib><creatorcontrib>Vurma, Mustafa</creatorcontrib><creatorcontrib>DeMichele, Stephen J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marriage, Barbara J.</au><au>Williams, Jennifer A.</au><au>Choe, Yong S.</au><au>Maki, Kevin C.</au><au>Vurma, Mustafa</au><au>DeMichele, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2017-11-28</date><risdate>2017</risdate><volume>118</volume><issue>10</issue><spage>813</spage><epage>821</epage><pages>813-821</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>With the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action. The primary objective of this study was to gain an understanding of how a new formulation technology (mixture of mono- and diglycerides (MDG)), affected lutein absorption. Subjects (n 24) were randomised in a cross-over, double-blind study to receive a single dose of 6 mg lutein (FloraGLO 20 %) provided as capsules containing either high-oleic safflower (SAF) oil or a MDG oil. Subjects receiving a single dose of lutein in MDG showed a significantly greater change from baseline (0 h) to 4, 6, 8, 12, 24, 48 and 336 h (P<0·05) and baseline adjusted AUC for plasma lutein at 48 and 336 h (P<0·001) as compared with subjects given lutein in SAF. Analysis of the 48 h absorption kinetics of lutein showed that the time to peak level of lutein (12 h) was the same for SAF and MDG groups, but the change in plasma lutein at 12 and 48 h were 129 and 320 % higher, respectively, for MDG compared with SAF. This difference continued as the adjusted AUC 0–48 and 0–336 h for the MDG group was 232 and 900 % higher, respectively, v. SAF. The study data show that by changing the lipid that is combined with a lutein supplement results in significant increases in lutein absorption in healthy adults.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29151374</pmid><doi>10.1017/S0007114517002963</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorption Adult Adults Area Under Curve Bioavailability Carotenoids Cataracts Chronic illnesses Chronic infection Cross-Over Studies Diet Dietary intake Dietary Supplements Diglycerides Diglycerides - pharmacology Double-Blind Method Double-blind studies Female Fistula Human and Clinical Nutrition Humans Intestinal Absorption Lipids Lutein Lutein - blood Lutein - pharmacokinetics Macular degeneration Male Monoglycerides Monoglycerides - pharmacology Nutrition research Oils & fats Oleic Acid - pharmacology Physiological effects R&D Randomization Reference Values Research & development Safflower Oil Triglycerides - pharmacology Xanthophylls |
| title | Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study |
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