Interleukin‐17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities
Psoriasis is a chronic, immune‐mediated, systemic inflammatory disease that is defined by a characteristic skin reaction produced when elevated levels of inflammatory cytokines such as interleukin (IL)‐17 alter the growth and differentiation of skin cells. The pathogenesis of comorbid conditions ass...
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| Veröffentlicht in: | Experimental dermatology 2018-02, Vol.27 (2), p.115-123 |
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| creator | Krueger, James G. Brunner, Patrick M. |
| description | Psoriasis is a chronic, immune‐mediated, systemic inflammatory disease that is defined by a characteristic skin reaction produced when elevated levels of inflammatory cytokines such as interleukin (IL)‐17 alter the growth and differentiation of skin cells. The pathogenesis of comorbid conditions associated with psoriasis, including psoriatic arthritis, cardiovascular disease, obesity, metabolic syndrome, liver disorders, renal disease and depression, is also largely affected by inflammation. In this review, we examine the effect of IL‐17 on the inflammatory pathways in a variety of different cell types, including keratinocytes, as well as epithelial cells of the colon, kidney, gut and liver. Additionally, we investigate the role of IL‐17 in mediating the psoriasis‐associated comorbidities detailed above. |
| doi_str_mv | 10.1111/exd.13467 |
| format | Article |
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The pathogenesis of comorbid conditions associated with psoriasis, including psoriatic arthritis, cardiovascular disease, obesity, metabolic syndrome, liver disorders, renal disease and depression, is also largely affected by inflammation. In this review, we examine the effect of IL‐17 on the inflammatory pathways in a variety of different cell types, including keratinocytes, as well as epithelial cells of the colon, kidney, gut and liver. 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| ispartof | Experimental dermatology, 2018-02, Vol.27 (2), p.115-123 |
| issn | 0906-6705 1600-0625 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Arthritis cardiovascular disease Cardiovascular Diseases - pathology Cell Differentiation Cell Proliferation Colon Comorbidity Cytokines Cytokines - metabolism Depression - pathology Epithelial cells Humans Hypertension - pathology Inflammation - pathology Interleukin 17 Interleukin-17 - metabolism keratinocyte Keratinocytes Keratinocytes - cytology Liver diseases Liver Diseases - pathology Mental depression Metabolic syndrome Metabolic Syndrome - pathology Mice obesity Psoriasis Psoriasis - pathology Psoriatic arthritis review Skin - pathology |
| title | Interleukin‐17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities |
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