Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance

The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large proportion of breast cancers, and in some systems interferes with chemotherapy-mediated proapoptotic signaling through c-Jun-NH(2)-terminal kinase (JNK). We therefore sought to examine whether MKP-1 is a medi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-05, Vol.67 (9), p.4459-4466
Hauptverfasser:	SMALL, George W, SHI, Yue Y, HIGGINS, Linda S, ORLOWSKIL, Robert Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Doxorubicin - pharmacology Drug Interactions Drug Resistance, Neoplasm Dual Specificity Phosphatase 1 Enzyme Activation - drug effects Gynecology. Andrology. Obstetrics Humans Immediate-Early Proteins - antagonists & inhibitors Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Indoles - pharmacology Mammary gland diseases MAP Kinase Kinase 4 - metabolism Mechlorethamine - pharmacology Medical sciences p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Paclitaxel - pharmacology Pharmacology. Drug treatments Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Protein Phosphatase 1 Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Tumors
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