Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices
Purpose: The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronical...
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| Veröffentlicht in: | International journal of artificial organs 2018-02, Vol.41 (2), p.129-132 |
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| container_title | International journal of artificial organs |
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| creator | Luc, Jessica G.Y. Pierre, Clifford A. Phan, Kevin Vahedein, Yashar S. Liberson, Alexander S. Cornwell, William K. Phillips, Steven J. Tchantchaleishvili, Vakhtang |
| description | Purpose:
The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model.
Methods:
Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model. The other source of production from capillary ultrafiltrate spaces was accounted for by the mass conservation equation. The primary CSF absorption sites (i.e., arachnoid granulations) were treated as the outlet boundary conditions. We established a low pulse wave to represent patients with a CF-LVAD.
Results:
From the model, low pulse conditions resulted in a reduction in CSF pressure amplitude and velocity though the overall flow rate was unchanged.
Conclusions:
The existing FSI model is not a suitable representation of CSF flow in CF-LVAD patients. More studies are needed to elucidate the role of pulsatility in CSF flow and the compensatory changes in CSF production and absorption that occur in patients with CF-LVADs in whom pulsatility is diminished. |
| doi_str_mv | 10.5301/ijao.5000657 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1966244558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.5301_ijao.5000657</sage_id><sourcerecordid>1966244558</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-573a51b1efa7778889eebcba3527d337e284b22f267be98c2f99f54f8dd26c083</originalsourceid><addsrcrecordid>eNptkctuFDEQRS0URIbALmtkKRuQ6OBH-9HLKCKAFIkNrFtudzl45GkPfiTKT-Sb8WQmREKsXLLPveWqi9ApJeeCE_rJr008F4QQKdQLtKKK9Z0kPTlCK8IH2vFB62P0Ouc1IVT2vXiFjtlAe00YX6GHq1D9jHNJ1ZaaAPulQDK2-LjgTZwhYLOYcJ99xtFhCwmmFPPWt0vsHrXWJ1uDeVT4BW9bBUvJ-M6XX9jGpfilxpo7F-IdDuAKvm3vye9ECZvcrAue4dZbyG_QS2dChreH8wT9vPr84_Jrd_39y7fLi-vOcsFLJxQ3gk4UnFFKaa0HgMlOhgumZs4VMN1PjDkm1QSDtswNgxO90_PMpCWan6D3e99tir8r5DJufLYQglmg_XWkg5Ss7Urs0LN_0HWsqY2fR0al4kRILhv1cU_Ztp2cwI3b5Dcm3Y-UjLucxl1O4yGnhr87mNZpA_Nf-CmYBnzYA9ncwHPH_5r9AR66ny8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2167305636</pqid></control><display><type>article</type><title>Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices</title><source>SAGE Complete</source><creator>Luc, Jessica G.Y. ; Pierre, Clifford A. ; Phan, Kevin ; Vahedein, Yashar S. ; Liberson, Alexander S. ; Cornwell, William K. ; Phillips, Steven J. ; Tchantchaleishvili, Vakhtang</creator><creatorcontrib>Luc, Jessica G.Y. ; Pierre, Clifford A. ; Phan, Kevin ; Vahedein, Yashar S. ; Liberson, Alexander S. ; Cornwell, William K. ; Phillips, Steven J. ; Tchantchaleishvili, Vakhtang</creatorcontrib><description>Purpose:
The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model.
Methods:
Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model. The other source of production from capillary ultrafiltrate spaces was accounted for by the mass conservation equation. The primary CSF absorption sites (i.e., arachnoid granulations) were treated as the outlet boundary conditions. We established a low pulse wave to represent patients with a CF-LVAD.
Results:
From the model, low pulse conditions resulted in a reduction in CSF pressure amplitude and velocity though the overall flow rate was unchanged.
Conclusions:
The existing FSI model is not a suitable representation of CSF flow in CF-LVAD patients. More studies are needed to elucidate the role of pulsatility in CSF flow and the compensatory changes in CSF production and absorption that occur in patients with CF-LVADs in whom pulsatility is diminished.</description><identifier>ISSN: 0391-3988</identifier><identifier>EISSN: 1724-6040</identifier><identifier>DOI: 10.5301/ijao.5000657</identifier><identifier>PMID: 29148023</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorption ; Arachnoid ; Boundary conditions ; Cerebrospinal fluid ; Computation ; Computer applications ; Conservation equations ; Flow velocity ; Fluid-structure interaction ; Granulation ; Heart ; Interaction models ; Patients ; Pressure ; Ventricle ; Ventricular assist devices</subject><ispartof>International journal of artificial organs, 2018-02, Vol.41 (2), p.129-132</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Wichtig Editore s.r.l. Feb 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-573a51b1efa7778889eebcba3527d337e284b22f267be98c2f99f54f8dd26c083</citedby><cites>FETCH-LOGICAL-c353t-573a51b1efa7778889eebcba3527d337e284b22f267be98c2f99f54f8dd26c083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/ijao.5000657$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/ijao.5000657$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29148023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luc, Jessica G.Y.</creatorcontrib><creatorcontrib>Pierre, Clifford A.</creatorcontrib><creatorcontrib>Phan, Kevin</creatorcontrib><creatorcontrib>Vahedein, Yashar S.</creatorcontrib><creatorcontrib>Liberson, Alexander S.</creatorcontrib><creatorcontrib>Cornwell, William K.</creatorcontrib><creatorcontrib>Phillips, Steven J.</creatorcontrib><creatorcontrib>Tchantchaleishvili, Vakhtang</creatorcontrib><title>Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices</title><title>International journal of artificial organs</title><addtitle>Int J Artif Organs</addtitle><description>Purpose:
The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model.
Methods:
Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model. The other source of production from capillary ultrafiltrate spaces was accounted for by the mass conservation equation. The primary CSF absorption sites (i.e., arachnoid granulations) were treated as the outlet boundary conditions. We established a low pulse wave to represent patients with a CF-LVAD.
Results:
From the model, low pulse conditions resulted in a reduction in CSF pressure amplitude and velocity though the overall flow rate was unchanged.
Conclusions:
The existing FSI model is not a suitable representation of CSF flow in CF-LVAD patients. More studies are needed to elucidate the role of pulsatility in CSF flow and the compensatory changes in CSF production and absorption that occur in patients with CF-LVADs in whom pulsatility is diminished.</description><subject>Absorption</subject><subject>Arachnoid</subject><subject>Boundary conditions</subject><subject>Cerebrospinal fluid</subject><subject>Computation</subject><subject>Computer applications</subject><subject>Conservation equations</subject><subject>Flow velocity</subject><subject>Fluid-structure interaction</subject><subject>Granulation</subject><subject>Heart</subject><subject>Interaction models</subject><subject>Patients</subject><subject>Pressure</subject><subject>Ventricle</subject><subject>Ventricular assist devices</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNptkctuFDEQRS0URIbALmtkKRuQ6OBH-9HLKCKAFIkNrFtudzl45GkPfiTKT-Sb8WQmREKsXLLPveWqi9ApJeeCE_rJr008F4QQKdQLtKKK9Z0kPTlCK8IH2vFB62P0Ouc1IVT2vXiFjtlAe00YX6GHq1D9jHNJ1ZaaAPulQDK2-LjgTZwhYLOYcJ99xtFhCwmmFPPWt0vsHrXWJ1uDeVT4BW9bBUvJ-M6XX9jGpfilxpo7F-IdDuAKvm3vye9ECZvcrAue4dZbyG_QS2dChreH8wT9vPr84_Jrd_39y7fLi-vOcsFLJxQ3gk4UnFFKaa0HgMlOhgumZs4VMN1PjDkm1QSDtswNgxO90_PMpCWan6D3e99tir8r5DJufLYQglmg_XWkg5Ss7Urs0LN_0HWsqY2fR0al4kRILhv1cU_Ztp2cwI3b5Dcm3Y-UjLucxl1O4yGnhr87mNZpA_Nf-CmYBnzYA9ncwHPH_5r9AR66ny8</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Luc, Jessica G.Y.</creator><creator>Pierre, Clifford A.</creator><creator>Phan, Kevin</creator><creator>Vahedein, Yashar S.</creator><creator>Liberson, Alexander S.</creator><creator>Cornwell, William K.</creator><creator>Phillips, Steven J.</creator><creator>Tchantchaleishvili, Vakhtang</creator><general>SAGE Publications</general><general>Wichtig Editore s.r.l</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices</title><author>Luc, Jessica G.Y. ; Pierre, Clifford A. ; Phan, Kevin ; Vahedein, Yashar S. ; Liberson, Alexander S. ; Cornwell, William K. ; Phillips, Steven J. ; Tchantchaleishvili, Vakhtang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-573a51b1efa7778889eebcba3527d337e284b22f267be98c2f99f54f8dd26c083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Absorption</topic><topic>Arachnoid</topic><topic>Boundary conditions</topic><topic>Cerebrospinal fluid</topic><topic>Computation</topic><topic>Computer applications</topic><topic>Conservation equations</topic><topic>Flow velocity</topic><topic>Fluid-structure interaction</topic><topic>Granulation</topic><topic>Heart</topic><topic>Interaction models</topic><topic>Patients</topic><topic>Pressure</topic><topic>Ventricle</topic><topic>Ventricular assist devices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luc, Jessica G.Y.</creatorcontrib><creatorcontrib>Pierre, Clifford A.</creatorcontrib><creatorcontrib>Phan, Kevin</creatorcontrib><creatorcontrib>Vahedein, Yashar S.</creatorcontrib><creatorcontrib>Liberson, Alexander S.</creatorcontrib><creatorcontrib>Cornwell, William K.</creatorcontrib><creatorcontrib>Phillips, Steven J.</creatorcontrib><creatorcontrib>Tchantchaleishvili, Vakhtang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luc, Jessica G.Y.</au><au>Pierre, Clifford A.</au><au>Phan, Kevin</au><au>Vahedein, Yashar S.</au><au>Liberson, Alexander S.</au><au>Cornwell, William K.</au><au>Phillips, Steven J.</au><au>Tchantchaleishvili, Vakhtang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>41</volume><issue>2</issue><spage>129</spage><epage>132</epage><pages>129-132</pages><issn>0391-3988</issn><eissn>1724-6040</eissn><abstract>Purpose:
The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model.
Methods:
Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model. The other source of production from capillary ultrafiltrate spaces was accounted for by the mass conservation equation. The primary CSF absorption sites (i.e., arachnoid granulations) were treated as the outlet boundary conditions. We established a low pulse wave to represent patients with a CF-LVAD.
Results:
From the model, low pulse conditions resulted in a reduction in CSF pressure amplitude and velocity though the overall flow rate was unchanged.
Conclusions:
The existing FSI model is not a suitable representation of CSF flow in CF-LVAD patients. More studies are needed to elucidate the role of pulsatility in CSF flow and the compensatory changes in CSF production and absorption that occur in patients with CF-LVADs in whom pulsatility is diminished.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29148023</pmid><doi>10.5301/ijao.5000657</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0391-3988 |
| ispartof | International journal of artificial organs, 2018-02, Vol.41 (2), p.129-132 |
| issn | 0391-3988 1724-6040 |
| language | eng |
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| source | SAGE Complete |
| subjects | Absorption Arachnoid Boundary conditions Cerebrospinal fluid Computation Computer applications Conservation equations Flow velocity Fluid-structure interaction Granulation Heart Interaction models Patients Pressure Ventricle Ventricular assist devices |
| title | Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with continuous-flow left ventricular assist devices |
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