Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes
Resistance to bovine spongiform encephalopathy (BSE) that is significantly associated with insertion/deletion ( indel ) polymorphisms at two loci (putative promoter and intron 1) on the prion protein gene ( PRNP ) in cattle has been well documented. Studies suggest that the insertion alleles are rel...
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| description | Resistance to bovine spongiform encephalopathy (BSE) that is significantly associated with insertion/deletion (
indel
) polymorphisms at two loci (putative promoter and intron 1) on the prion protein gene (
PRNP
) in cattle has been well documented. Studies suggest that the insertion alleles are related to BSE resistance. Until recently, BSE has never been reported in water buffaloes (unlike cattle). Previous studies have demonstrated that the
PRNP
gene in water buffalo consists mostly of insertion alleles at both loci; nevertheless, whether or not water buffaloes are genetically resistant to BSE and the role of
indel
polymorphisms in their resistance status is not clear. We examined the coding region of
PRNP
to determine the nucleotide and octapeptide-repeat (octarepeats) variations of Anatolian, Murrah and Murrah × Anatolian (M × A) water buffaloes. Three synonymous single nucleotide polymorphisms (SNP) at positions 126, 234, and 285, and a non-synonymous SNP at position 322 (G108S) were detected. Triplet G/A/T base substitutions were observed at position 126 and two additional genotypes, T/A and T/G, at this position were determined. We also found six octarepeats that indicated the presence of the wild-type
PRNP6
allele in the coding region. To the best of our knowledge, this is the first report of the T/A and T/G genotypes in water buffaloes. |
| doi_str_mv | 10.1007/s11250-017-1471-9 |
| format | Article |
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indel
) polymorphisms at two loci (putative promoter and intron 1) on the prion protein gene (
PRNP
) in cattle has been well documented. Studies suggest that the insertion alleles are related to BSE resistance. Until recently, BSE has never been reported in water buffaloes (unlike cattle). Previous studies have demonstrated that the
PRNP
gene in water buffalo consists mostly of insertion alleles at both loci; nevertheless, whether or not water buffaloes are genetically resistant to BSE and the role of
indel
polymorphisms in their resistance status is not clear. We examined the coding region of
PRNP
to determine the nucleotide and octapeptide-repeat (octarepeats) variations of Anatolian, Murrah and Murrah × Anatolian (M × A) water buffaloes. Three synonymous single nucleotide polymorphisms (SNP) at positions 126, 234, and 285, and a non-synonymous SNP at position 322 (G108S) were detected. Triplet G/A/T base substitutions were observed at position 126 and two additional genotypes, T/A and T/G, at this position were determined. We also found six octarepeats that indicated the presence of the wild-type
PRNP6
allele in the coding region. To the best of our knowledge, this is the first report of the T/A and T/G genotypes in water buffaloes.</description><identifier>ISSN: 0049-4747</identifier><identifier>EISSN: 1573-7438</identifier><identifier>DOI: 10.1007/s11250-017-1471-9</identifier><identifier>PMID: 29147935</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alleles ; Biomedical and Life Sciences ; Bovidae ; Bovine spongiform encephalopathy ; Buffalo ; Cattle ; Gene deletion ; Genotypes ; Insertion ; Life Sciences ; Loci ; Prion protein ; Regular Articles ; Single-nucleotide polymorphism ; Veterinary Medicine/Veterinary Science ; Water resistance ; Zoology</subject><ispartof>Tropical animal health and production, 2018-03, Vol.50 (3), p.573-579</ispartof><rights>Springer Science+Business Media B.V., part of Springer Nature 2017</rights><rights>Tropical Animal Health and Production is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-32e01d4b18e7a4c9228b3b5b3163b6d32f5c14cffd1f39fc8c617f9eac0c7f3d3</citedby><cites>FETCH-LOGICAL-c372t-32e01d4b18e7a4c9228b3b5b3163b6d32f5c14cffd1f39fc8c617f9eac0c7f3d3</cites><orcidid>0000-0003-2705-2831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11250-017-1471-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11250-017-1471-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29147935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaman, Yalçın</creatorcontrib><creatorcontrib>Ün, Cemal</creatorcontrib><title>Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes</title><title>Tropical animal health and production</title><addtitle>Trop Anim Health Prod</addtitle><addtitle>Trop Anim Health Prod</addtitle><description>Resistance to bovine spongiform encephalopathy (BSE) that is significantly associated with insertion/deletion (
indel
) polymorphisms at two loci (putative promoter and intron 1) on the prion protein gene (
PRNP
) in cattle has been well documented. Studies suggest that the insertion alleles are related to BSE resistance. Until recently, BSE has never been reported in water buffaloes (unlike cattle). Previous studies have demonstrated that the
PRNP
gene in water buffalo consists mostly of insertion alleles at both loci; nevertheless, whether or not water buffaloes are genetically resistant to BSE and the role of
indel
polymorphisms in their resistance status is not clear. We examined the coding region of
PRNP
to determine the nucleotide and octapeptide-repeat (octarepeats) variations of Anatolian, Murrah and Murrah × Anatolian (M × A) water buffaloes. Three synonymous single nucleotide polymorphisms (SNP) at positions 126, 234, and 285, and a non-synonymous SNP at position 322 (G108S) were detected. Triplet G/A/T base substitutions were observed at position 126 and two additional genotypes, T/A and T/G, at this position were determined. We also found six octarepeats that indicated the presence of the wild-type
PRNP6
allele in the coding region. To the best of our knowledge, this is the first report of the T/A and T/G genotypes in water buffaloes.</description><subject>Alleles</subject><subject>Biomedical and Life Sciences</subject><subject>Bovidae</subject><subject>Bovine spongiform encephalopathy</subject><subject>Buffalo</subject><subject>Cattle</subject><subject>Gene deletion</subject><subject>Genotypes</subject><subject>Insertion</subject><subject>Life Sciences</subject><subject>Loci</subject><subject>Prion protein</subject><subject>Regular Articles</subject><subject>Single-nucleotide polymorphism</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Water resistance</subject><subject>Zoology</subject><issn>0049-4747</issn><issn>1573-7438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kdtuFSEUhonR2G31AbwxJN7UpCinGYbLpvGU1NoYvSYMLHanmQ1bYDS-gY8t012NMZELWAu-9bPgR-gpoy8ZpepVYYx3lFCmCJOKEX0PbVinBFFSDPfRhlKpiVRSHaFHpdxQ2qqG_iE64rrxWnQb9PNycTOkOnnANnqcXLV72K85ybAHW_E3mydbpxQLTgHXa8D73LI2pwpTxC75KW7xFiLgk6tPl1cvcNs9i7amebLxFH9YcrbXp7f6LqdSxgwef7cVMh6XEOycoDxGD1pQ4Mndeoy-vHn9-fwdufj49v352QVxQvFKBAfKvBzZAMpKpzkfRjF2o2C9GHsveOgcky4Ez4LQwQ2uZyposI46FYQXx-jkoNva_7pAqWY3FQfzbCOkpRim-57LNmhDn_-D3qQlx9bdSknN-oHrRrEDdfu0DMG079nZ_MMwalabzMEm02wyq01mrXl2p7yMO_B_Kn770gB-AEo7ilvIf139X9VfZe-eYg</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Yaman, Yalçın</creator><creator>Ün, Cemal</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2705-2831</orcidid></search><sort><creationdate>20180301</creationdate><title>Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes</title><author>Yaman, Yalçın ; Ün, Cemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-32e01d4b18e7a4c9228b3b5b3163b6d32f5c14cffd1f39fc8c617f9eac0c7f3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Biomedical and Life Sciences</topic><topic>Bovidae</topic><topic>Bovine spongiform encephalopathy</topic><topic>Buffalo</topic><topic>Cattle</topic><topic>Gene deletion</topic><topic>Genotypes</topic><topic>Insertion</topic><topic>Life Sciences</topic><topic>Loci</topic><topic>Prion protein</topic><topic>Regular Articles</topic><topic>Single-nucleotide polymorphism</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Water resistance</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaman, Yalçın</creatorcontrib><creatorcontrib>Ün, Cemal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical animal health and production</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaman, Yalçın</au><au>Ün, Cemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes</atitle><jtitle>Tropical animal health and production</jtitle><stitle>Trop Anim Health Prod</stitle><addtitle>Trop Anim Health Prod</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>50</volume><issue>3</issue><spage>573</spage><epage>579</epage><pages>573-579</pages><issn>0049-4747</issn><eissn>1573-7438</eissn><abstract>Resistance to bovine spongiform encephalopathy (BSE) that is significantly associated with insertion/deletion (
indel
) polymorphisms at two loci (putative promoter and intron 1) on the prion protein gene (
PRNP
) in cattle has been well documented. Studies suggest that the insertion alleles are related to BSE resistance. Until recently, BSE has never been reported in water buffaloes (unlike cattle). Previous studies have demonstrated that the
PRNP
gene in water buffalo consists mostly of insertion alleles at both loci; nevertheless, whether or not water buffaloes are genetically resistant to BSE and the role of
indel
polymorphisms in their resistance status is not clear. We examined the coding region of
PRNP
to determine the nucleotide and octapeptide-repeat (octarepeats) variations of Anatolian, Murrah and Murrah × Anatolian (M × A) water buffaloes. Three synonymous single nucleotide polymorphisms (SNP) at positions 126, 234, and 285, and a non-synonymous SNP at position 322 (G108S) were detected. Triplet G/A/T base substitutions were observed at position 126 and two additional genotypes, T/A and T/G, at this position were determined. We also found six octarepeats that indicated the presence of the wild-type
PRNP6
allele in the coding region. To the best of our knowledge, this is the first report of the T/A and T/G genotypes in water buffaloes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29147935</pmid><doi>10.1007/s11250-017-1471-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2705-2831</orcidid></addata></record> |
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| ispartof | Tropical animal health and production, 2018-03, Vol.50 (3), p.573-579 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Alleles Biomedical and Life Sciences Bovidae Bovine spongiform encephalopathy Buffalo Cattle Gene deletion Genotypes Insertion Life Sciences Loci Prion protein Regular Articles Single-nucleotide polymorphism Veterinary Medicine/Veterinary Science Water resistance Zoology |
| title | Nucleotide and octapeptide-repeat variations of the prion protein coding gene (PRNP) in Anatolian, Murrah, and crossbred water buffaloes |
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