Modelling direct DNA damage for gold nanoparticle enhanced proton therapy

Gold nanoparticles have been proven as potential radiosensitizer when combined with protons. Initially the radiosensitization effect was attributed to the physical interactions of radiation with the gold and the production of secondary electrons that induce DNA damage. However, emerging data challen...

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Veröffentlicht in:	Nanoscale 2017-12, Vol.9 (46), p.18413-18422
Hauptverfasser:	Sotiropoulos, Marios, Henthorn, Nicholas T, Warmenhoven, John W, Mackay, Ranald I, Kirkby, Karen J, Merchant, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Complexity Deoxyribonucleic acid DNA DNA Damage Gold Metal Nanoparticles Models, Theoretical Monte Carlo Method Nanoparticles Proton energy Proton irradiation Proton Therapy Radiation damage Radiation-Sensitizing Agents - chemistry Tissue Distribution
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