Vasohibins encode tubulin detyrosinating activity

Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of the C-terminal tyrosine of α-tubulin. The enzymes responsible for detyrosination, an activity first observed 40 years ago, have remained elusi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-12, Vol.358 (6369), p.1453-1456
Hauptverfasser:	Nieuwenhuis, Joppe, Adamopoulos, Athanassios, Bleijerveld, Onno B., Mazouzi, Abdelghani, Stickel, Elmer, Celie, Patrick, Altelaar, Maarten, Knipscheer, Puck, Perrakis, Anastassis, Blomen, Vincent A., Brummelkamp, Thijn R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Brain Carboxypeptidase Enzymes Genetic screening Microtubules Regulators Tubulin Tyrosine
Online-Zugang:	Volltext
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