Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry
•We are the first to study DFSA by mass spectrometry in Asian country.•We detect new psychoactive substances in urine of DFSA by LC–MS/MS.•We detect drug abuse, benzodiazepine and new psychoactive substances in urine of DFSA. According to domestic and international epidemiological investigation, the...
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| Veröffentlicht in: | Forensic science international 2018-01, Vol.282, p.35-40 |
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| creator | Lee, Hei Hwa Chen, Suen Chi Lee, Jong Feng Lin, Hsin Yu Chen, Bai Hsiun |
| description | •We are the first to study DFSA by mass spectrometry in Asian country.•We detect new psychoactive substances in urine of DFSA by LC–MS/MS.•We detect drug abuse, benzodiazepine and new psychoactive substances in urine of DFSA.
According to domestic and international epidemiological investigation, the proportion of substance involved sexual assault has the trend of ascent. In the past, laboratory methods that investigated urine sample of the sexual assault victims was to screen with enzyme immunoassay and then confirmed with mass spectrometry. The objective of the study is to simultaneously identify abused drugs in 126 decoded urine samples of sexual assault victims by liquid chromatography tandem mass spectrometry. The instrument was operated in multiple-reaction monitoring with an electro-spray positive ionization mode. Chromatograms were separated with ACE5 C18 column on a gradient of acetonitrile. After liquid–liquid extraction, samples were passed through a 0.22μm PVDF filter before injection into the system. The limits of quantitation ranged from 0.2 to 10ng/mL. The precision (CV) results were below 12.9% (intraday) and 15.0% (interday). The intraday accuracy ranged from 84.8 to 121.0%, interday accuracy ranged from 72.0 to 117.3%. We found that 29 (23.0%) were positive for drugs. The most common drug identified is flunitrazepam (11.1%), followed by nimetazepam and ketamine (7.9%), some new psychoactive substances, such as 2C-B, mephedrone, methylone, PMA and PMMA were also identified. We identified abused drugs, benzodiazepines, and new psychoactive substances in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry. |
| doi_str_mv | 10.1016/j.forsciint.2017.11.006 |
| format | Article |
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According to domestic and international epidemiological investigation, the proportion of substance involved sexual assault has the trend of ascent. In the past, laboratory methods that investigated urine sample of the sexual assault victims was to screen with enzyme immunoassay and then confirmed with mass spectrometry. The objective of the study is to simultaneously identify abused drugs in 126 decoded urine samples of sexual assault victims by liquid chromatography tandem mass spectrometry. The instrument was operated in multiple-reaction monitoring with an electro-spray positive ionization mode. Chromatograms were separated with ACE5 C18 column on a gradient of acetonitrile. After liquid–liquid extraction, samples were passed through a 0.22μm PVDF filter before injection into the system. The limits of quantitation ranged from 0.2 to 10ng/mL. The precision (CV) results were below 12.9% (intraday) and 15.0% (interday). The intraday accuracy ranged from 84.8 to 121.0%, interday accuracy ranged from 72.0 to 117.3%. We found that 29 (23.0%) were positive for drugs. The most common drug identified is flunitrazepam (11.1%), followed by nimetazepam and ketamine (7.9%), some new psychoactive substances, such as 2C-B, mephedrone, methylone, PMA and PMMA were also identified. We identified abused drugs, benzodiazepines, and new psychoactive substances in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2017.11.006</identifier><identifier>PMID: 29149685</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Accuracy ; Acetonitrile ; Acids ; Alcohol ; Benzodiazepines ; Calibration ; Chromatography ; Cocaine ; Date rape ; Drug abuse ; Drugs ; Enzyme immunoassay ; Enzymes ; Epidemiology ; Flunitrazepam ; Forensic sciences ; Immunoassay ; Investigations ; Ionization ; Ions ; Ketamine ; Laboratories ; Laboratory methods ; Liquid chromatography ; Liquid chromatography tandem mass spectrometry ; Liquid-liquid extraction ; Mass spectrometry ; Mass spectroscopy ; Methadone ; Methamphetamine ; New psychoactive substances ; Polymethyl methacrylate ; Polymethylmethacrylate ; Quality control ; Quantitation ; Scientific imaging ; Sex crimes ; Sexual assault ; Spectroscopy ; Urine</subject><ispartof>Forensic science international, 2018-01, Vol.282, p.35-40</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-a9c680b7f33cd448c4f483bd5eabb0dcc31f61071a099cb6ccb3de32ad6c0e1b3</citedby><cites>FETCH-LOGICAL-c425t-a9c680b7f33cd448c4f483bd5eabb0dcc31f61071a099cb6ccb3de32ad6c0e1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1983445266?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29149685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hei Hwa</creatorcontrib><creatorcontrib>Chen, Suen Chi</creatorcontrib><creatorcontrib>Lee, Jong Feng</creatorcontrib><creatorcontrib>Lin, Hsin Yu</creatorcontrib><creatorcontrib>Chen, Bai Hsiun</creatorcontrib><title>Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>•We are the first to study DFSA by mass spectrometry in Asian country.•We detect new psychoactive substances in urine of DFSA by LC–MS/MS.•We detect drug abuse, benzodiazepine and new psychoactive substances in urine of DFSA.
According to domestic and international epidemiological investigation, the proportion of substance involved sexual assault has the trend of ascent. In the past, laboratory methods that investigated urine sample of the sexual assault victims was to screen with enzyme immunoassay and then confirmed with mass spectrometry. The objective of the study is to simultaneously identify abused drugs in 126 decoded urine samples of sexual assault victims by liquid chromatography tandem mass spectrometry. The instrument was operated in multiple-reaction monitoring with an electro-spray positive ionization mode. Chromatograms were separated with ACE5 C18 column on a gradient of acetonitrile. After liquid–liquid extraction, samples were passed through a 0.22μm PVDF filter before injection into the system. The limits of quantitation ranged from 0.2 to 10ng/mL. The precision (CV) results were below 12.9% (intraday) and 15.0% (interday). The intraday accuracy ranged from 84.8 to 121.0%, interday accuracy ranged from 72.0 to 117.3%. We found that 29 (23.0%) were positive for drugs. The most common drug identified is flunitrazepam (11.1%), followed by nimetazepam and ketamine (7.9%), some new psychoactive substances, such as 2C-B, mephedrone, methylone, PMA and PMMA were also identified. We identified abused drugs, benzodiazepines, and new psychoactive substances in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry.</description><subject>Accuracy</subject><subject>Acetonitrile</subject><subject>Acids</subject><subject>Alcohol</subject><subject>Benzodiazepines</subject><subject>Calibration</subject><subject>Chromatography</subject><subject>Cocaine</subject><subject>Date rape</subject><subject>Drug abuse</subject><subject>Drugs</subject><subject>Enzyme immunoassay</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Flunitrazepam</subject><subject>Forensic sciences</subject><subject>Immunoassay</subject><subject>Investigations</subject><subject>Ionization</subject><subject>Ions</subject><subject>Ketamine</subject><subject>Laboratories</subject><subject>Laboratory methods</subject><subject>Liquid chromatography</subject><subject>Liquid chromatography tandem mass spectrometry</subject><subject>Liquid-liquid extraction</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Methadone</subject><subject>Methamphetamine</subject><subject>New psychoactive substances</subject><subject>Polymethyl methacrylate</subject><subject>Polymethylmethacrylate</subject><subject>Quality control</subject><subject>Quantitation</subject><subject>Scientific imaging</subject><subject>Sex crimes</subject><subject>Sexual assault</subject><subject>Spectroscopy</subject><subject>Urine</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtv1DAUhS1ERaeFvwCW2LBJaseJkyyrCihSJRYta8uPm-kdJfHUj6oj_jyupnTBhpUX9zvn-p5DyCfOas64vNjVkw_RIq6pbhjva85rxuQbsuFD31SyGcRbsmGiHyvWi-GUnMW4Y4x1XSPfkdNm5O0oh25Dft_ikuekV_A5UhfylqKDNeGEVif0K8WV5oArUD_RCE9Zz1THqIuIPqJNuERqDjRHXLd0xoeMjtr74Bed_Dbo_f2BFncHC12KjMY92FSmkMLhPTmZ9Bzhw8t7Tn59-3p3dV3d_Pz-4-ryprJt06VKj1YOzPSTENa17WDbqR2EcR1oY5izVvBJctZzzcbRGmmtEQ5Eo520DLgR5-TL0Xcf_EOGmNSC0cI8H69WfJSyER3nrKCf_0F3Poe1_K5Qg2jbkp8sVH-kbPAxBpjUPuCiw0Fxpp77UTv12o967kdxrko_RfnxxT-bBdyr7m8hBbg8AlACeUQIqrjAasFhKMkp5_G_S_4AM4qp7g</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Lee, Hei Hwa</creator><creator>Chen, Suen Chi</creator><creator>Lee, Jong Feng</creator><creator>Lin, Hsin Yu</creator><creator>Chen, Bai Hsiun</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry</title><author>Lee, Hei Hwa ; Chen, Suen Chi ; Lee, Jong Feng ; Lin, Hsin Yu ; Chen, Bai Hsiun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a9c680b7f33cd448c4f483bd5eabb0dcc31f61071a099cb6ccb3de32ad6c0e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Accuracy</topic><topic>Acetonitrile</topic><topic>Acids</topic><topic>Alcohol</topic><topic>Benzodiazepines</topic><topic>Calibration</topic><topic>Chromatography</topic><topic>Cocaine</topic><topic>Date rape</topic><topic>Drug abuse</topic><topic>Drugs</topic><topic>Enzyme immunoassay</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Flunitrazepam</topic><topic>Forensic sciences</topic><topic>Immunoassay</topic><topic>Investigations</topic><topic>Ionization</topic><topic>Ions</topic><topic>Ketamine</topic><topic>Laboratories</topic><topic>Laboratory methods</topic><topic>Liquid chromatography</topic><topic>Liquid chromatography tandem mass spectrometry</topic><topic>Liquid-liquid extraction</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Methadone</topic><topic>Methamphetamine</topic><topic>New psychoactive substances</topic><topic>Polymethyl methacrylate</topic><topic>Polymethylmethacrylate</topic><topic>Quality control</topic><topic>Quantitation</topic><topic>Scientific imaging</topic><topic>Sex crimes</topic><topic>Sexual assault</topic><topic>Spectroscopy</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hei Hwa</creatorcontrib><creatorcontrib>Chen, Suen Chi</creatorcontrib><creatorcontrib>Lee, Jong Feng</creatorcontrib><creatorcontrib>Lin, Hsin Yu</creatorcontrib><creatorcontrib>Chen, Bai Hsiun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hei Hwa</au><au>Chen, Suen Chi</au><au>Lee, Jong Feng</au><au>Lin, Hsin Yu</au><au>Chen, Bai Hsiun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2018-01</date><risdate>2018</risdate><volume>282</volume><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>•We are the first to study DFSA by mass spectrometry in Asian country.•We detect new psychoactive substances in urine of DFSA by LC–MS/MS.•We detect drug abuse, benzodiazepine and new psychoactive substances in urine of DFSA.
According to domestic and international epidemiological investigation, the proportion of substance involved sexual assault has the trend of ascent. In the past, laboratory methods that investigated urine sample of the sexual assault victims was to screen with enzyme immunoassay and then confirmed with mass spectrometry. The objective of the study is to simultaneously identify abused drugs in 126 decoded urine samples of sexual assault victims by liquid chromatography tandem mass spectrometry. The instrument was operated in multiple-reaction monitoring with an electro-spray positive ionization mode. Chromatograms were separated with ACE5 C18 column on a gradient of acetonitrile. After liquid–liquid extraction, samples were passed through a 0.22μm PVDF filter before injection into the system. The limits of quantitation ranged from 0.2 to 10ng/mL. The precision (CV) results were below 12.9% (intraday) and 15.0% (interday). The intraday accuracy ranged from 84.8 to 121.0%, interday accuracy ranged from 72.0 to 117.3%. We found that 29 (23.0%) were positive for drugs. The most common drug identified is flunitrazepam (11.1%), followed by nimetazepam and ketamine (7.9%), some new psychoactive substances, such as 2C-B, mephedrone, methylone, PMA and PMMA were also identified. We identified abused drugs, benzodiazepines, and new psychoactive substances in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29149685</pmid><doi>10.1016/j.forsciint.2017.11.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Accuracy Acetonitrile Acids Alcohol Benzodiazepines Calibration Chromatography Cocaine Date rape Drug abuse Drugs Enzyme immunoassay Enzymes Epidemiology Flunitrazepam Forensic sciences Immunoassay Investigations Ionization Ions Ketamine Laboratories Laboratory methods Liquid chromatography Liquid chromatography tandem mass spectrometry Liquid-liquid extraction Mass spectrometry Mass spectroscopy Methadone Methamphetamine New psychoactive substances Polymethyl methacrylate Polymethylmethacrylate Quality control Quantitation Scientific imaging Sex crimes Sexual assault Spectroscopy Urine |
| title | Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry |
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