Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty
Pseudoaneurysms remain a significant complication after vascular procedures. We hypothesized that TGF-β (transforming growth factor-β) signaling plays a mechanistic role in the development of pseudoaneurysms. Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseu...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-01, Vol.38 (1), p.195-205 |
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| creator | Bai, Hualong Lee, Jung Seok Hu, Haidi Wang, Tun Isaji, Toshihiko Liu, Shirley Guo, Jianming Liu, Haiyang Wolf, Katharine Ono, Shun Guo, Xiangjiang Yatsula, Bogdan Xing, Ying Fahmy, Tarek M Dardik, Alan |
| description | Pseudoaneurysms remain a significant complication after vascular procedures. We hypothesized that TGF-β (transforming growth factor-β) signaling plays a mechanistic role in the development of pseudoaneurysms.
Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseudoaneurysms at 30 days, with increased smad2 phosphorylation in small pseudoaneurysms but not in large pseudoaneurysms; TGF-β1 receptors were increased in small pseudoaneurysms and preserved in large pseudoaneurysms. Delivery of TGF-β1 via nanoparticles covalently bonded to the patch stimulated smad2 phosphorylation both in vitro and in vivo and significantly decreased pseudoaneurysm formation (6.7%). Inhibition of TGF-β1 signaling with SB431542 decreased smad2 phosphorylation both in vitro and in vivo and significantly induced pseudoaneurysm formation by day 7 (66.7%).
Normal healing after aortic patch angioplasty is associated with increased TGF-β1 signaling, and recruitment of smad2 signaling may limit pseudoaneurysm formation; loss of TGF-β1 signaling is associated with the formation of large pseudoaneurysms. Enhancement of TGF-β1 signaling may be a potential mechanism to limit pseudoaneurysm formation after vascular intervention. |
| doi_str_mv | 10.1161/ATVBAHA.117.310372 |
| format | Article |
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Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseudoaneurysms at 30 days, with increased smad2 phosphorylation in small pseudoaneurysms but not in large pseudoaneurysms; TGF-β1 receptors were increased in small pseudoaneurysms and preserved in large pseudoaneurysms. Delivery of TGF-β1 via nanoparticles covalently bonded to the patch stimulated smad2 phosphorylation both in vitro and in vivo and significantly decreased pseudoaneurysm formation (6.7%). Inhibition of TGF-β1 signaling with SB431542 decreased smad2 phosphorylation both in vitro and in vivo and significantly induced pseudoaneurysm formation by day 7 (66.7%).
Normal healing after aortic patch angioplasty is associated with increased TGF-β1 signaling, and recruitment of smad2 signaling may limit pseudoaneurysm formation; loss of TGF-β1 signaling is associated with the formation of large pseudoaneurysms. Enhancement of TGF-β1 signaling may be a potential mechanism to limit pseudoaneurysm formation after vascular intervention.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.117.310372</identifier><identifier>PMID: 29146747</identifier><language>eng</language><publisher>United States</publisher><subject>Aneurysm, False - etiology ; Aneurysm, False - metabolism ; Aneurysm, False - pathology ; Aneurysm, False - prevention & control ; Angioplasty - adverse effects ; Angioplasty - instrumentation ; Animals ; Aorta - metabolism ; Aorta - pathology ; Aorta - surgery ; Aortic Aneurysm - etiology ; Aortic Aneurysm - metabolism ; Aortic Aneurysm - pathology ; Aortic Aneurysm - prevention & control ; Cells, Cultured ; Coated Materials, Biocompatible ; Male ; Mice ; Nanoparticles ; Pericardium - transplantation ; Phosphorylation ; Prosthesis Design ; Rats, Wistar ; Signal Transduction - drug effects ; Smad2 Protein - metabolism ; Time Factors ; Transforming Growth Factor beta1 - administration & dosage ; Wound Healing - drug effects</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2018-01, Vol.38 (1), p.195-205</ispartof><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3772-3b4733200f5b1a18a1d2b8ce4477f998272af2b453c4454cc8e98161335674053</citedby><cites>FETCH-LOGICAL-c3772-3b4733200f5b1a18a1d2b8ce4477f998272af2b453c4454cc8e98161335674053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29146747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Hualong</creatorcontrib><creatorcontrib>Lee, Jung Seok</creatorcontrib><creatorcontrib>Hu, Haidi</creatorcontrib><creatorcontrib>Wang, Tun</creatorcontrib><creatorcontrib>Isaji, Toshihiko</creatorcontrib><creatorcontrib>Liu, Shirley</creatorcontrib><creatorcontrib>Guo, Jianming</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Wolf, Katharine</creatorcontrib><creatorcontrib>Ono, Shun</creatorcontrib><creatorcontrib>Guo, Xiangjiang</creatorcontrib><creatorcontrib>Yatsula, Bogdan</creatorcontrib><creatorcontrib>Xing, Ying</creatorcontrib><creatorcontrib>Fahmy, Tarek M</creatorcontrib><creatorcontrib>Dardik, Alan</creatorcontrib><title>Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>Pseudoaneurysms remain a significant complication after vascular procedures. We hypothesized that TGF-β (transforming growth factor-β) signaling plays a mechanistic role in the development of pseudoaneurysms.
Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseudoaneurysms at 30 days, with increased smad2 phosphorylation in small pseudoaneurysms but not in large pseudoaneurysms; TGF-β1 receptors were increased in small pseudoaneurysms and preserved in large pseudoaneurysms. Delivery of TGF-β1 via nanoparticles covalently bonded to the patch stimulated smad2 phosphorylation both in vitro and in vivo and significantly decreased pseudoaneurysm formation (6.7%). Inhibition of TGF-β1 signaling with SB431542 decreased smad2 phosphorylation both in vitro and in vivo and significantly induced pseudoaneurysm formation by day 7 (66.7%).
Normal healing after aortic patch angioplasty is associated with increased TGF-β1 signaling, and recruitment of smad2 signaling may limit pseudoaneurysm formation; loss of TGF-β1 signaling is associated with the formation of large pseudoaneurysms. Enhancement of TGF-β1 signaling may be a potential mechanism to limit pseudoaneurysm formation after vascular intervention.</description><subject>Aneurysm, False - etiology</subject><subject>Aneurysm, False - metabolism</subject><subject>Aneurysm, False - pathology</subject><subject>Aneurysm, False - prevention & control</subject><subject>Angioplasty - adverse effects</subject><subject>Angioplasty - instrumentation</subject><subject>Animals</subject><subject>Aorta - metabolism</subject><subject>Aorta - pathology</subject><subject>Aorta - surgery</subject><subject>Aortic Aneurysm - etiology</subject><subject>Aortic Aneurysm - metabolism</subject><subject>Aortic Aneurysm - pathology</subject><subject>Aortic Aneurysm - prevention & control</subject><subject>Cells, Cultured</subject><subject>Coated Materials, Biocompatible</subject><subject>Male</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Pericardium - transplantation</subject><subject>Phosphorylation</subject><subject>Prosthesis Design</subject><subject>Rats, Wistar</subject><subject>Signal Transduction - drug effects</subject><subject>Smad2 Protein - metabolism</subject><subject>Time Factors</subject><subject>Transforming Growth Factor beta1 - administration & dosage</subject><subject>Wound Healing - drug effects</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQhS0EoqVwARbISzYp_o2TZUD0R6pEF4Wt5bhOa9TExXaEei0OwpkwamE186T3nmY-AG4xGmOc44dq9fZYzaokxJhiRAU5A0PMCctYTvPztCNRZjxnZACuQnhHCDFC0CUYkBKzXDAxBHLlVRca51vbbeDUu8-4hROlo_PZ9xeG825raxsDXAbTr53qTO8PoYWTlFDRug5WTTQeVs5Hq-FSRb2FVbexbr9TIR6uwUWjdsHcnOYIvE6eV0-zbPEynT9Vi0xTIUhGayYoJQg1vMYKFwqvSV1ow5gQTVkWRBDVkJpxqhnjTOvClEViQClPfyBOR-D-2Lv37qM3IcrWBm12u3Sx64PEZZ4TygqeJys5WrV3IXjTyL23rfIHiZH8BStPYJMQ8gg2he5O_X3dmvV_5I8k_QFkWnQN</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Bai, Hualong</creator><creator>Lee, Jung Seok</creator><creator>Hu, Haidi</creator><creator>Wang, Tun</creator><creator>Isaji, Toshihiko</creator><creator>Liu, Shirley</creator><creator>Guo, Jianming</creator><creator>Liu, Haiyang</creator><creator>Wolf, Katharine</creator><creator>Ono, Shun</creator><creator>Guo, Xiangjiang</creator><creator>Yatsula, Bogdan</creator><creator>Xing, Ying</creator><creator>Fahmy, Tarek M</creator><creator>Dardik, Alan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty</title><author>Bai, Hualong ; Lee, Jung Seok ; Hu, Haidi ; Wang, Tun ; Isaji, Toshihiko ; Liu, Shirley ; Guo, Jianming ; Liu, Haiyang ; Wolf, Katharine ; Ono, Shun ; Guo, Xiangjiang ; Yatsula, Bogdan ; Xing, Ying ; Fahmy, Tarek M ; Dardik, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3772-3b4733200f5b1a18a1d2b8ce4477f998272af2b453c4454cc8e98161335674053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aneurysm, False - etiology</topic><topic>Aneurysm, False - metabolism</topic><topic>Aneurysm, False - pathology</topic><topic>Aneurysm, False - prevention & control</topic><topic>Angioplasty - adverse effects</topic><topic>Angioplasty - instrumentation</topic><topic>Animals</topic><topic>Aorta - metabolism</topic><topic>Aorta - pathology</topic><topic>Aorta - surgery</topic><topic>Aortic Aneurysm - etiology</topic><topic>Aortic Aneurysm - metabolism</topic><topic>Aortic Aneurysm - pathology</topic><topic>Aortic Aneurysm - prevention & control</topic><topic>Cells, Cultured</topic><topic>Coated Materials, Biocompatible</topic><topic>Male</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Pericardium - transplantation</topic><topic>Phosphorylation</topic><topic>Prosthesis Design</topic><topic>Rats, Wistar</topic><topic>Signal Transduction - drug effects</topic><topic>Smad2 Protein - metabolism</topic><topic>Time Factors</topic><topic>Transforming Growth Factor beta1 - administration & dosage</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Hualong</creatorcontrib><creatorcontrib>Lee, Jung Seok</creatorcontrib><creatorcontrib>Hu, Haidi</creatorcontrib><creatorcontrib>Wang, Tun</creatorcontrib><creatorcontrib>Isaji, Toshihiko</creatorcontrib><creatorcontrib>Liu, Shirley</creatorcontrib><creatorcontrib>Guo, Jianming</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Wolf, Katharine</creatorcontrib><creatorcontrib>Ono, Shun</creatorcontrib><creatorcontrib>Guo, Xiangjiang</creatorcontrib><creatorcontrib>Yatsula, Bogdan</creatorcontrib><creatorcontrib>Xing, Ying</creatorcontrib><creatorcontrib>Fahmy, Tarek M</creatorcontrib><creatorcontrib>Dardik, Alan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Hualong</au><au>Lee, Jung Seok</au><au>Hu, Haidi</au><au>Wang, Tun</au><au>Isaji, Toshihiko</au><au>Liu, Shirley</au><au>Guo, Jianming</au><au>Liu, Haiyang</au><au>Wolf, Katharine</au><au>Ono, Shun</au><au>Guo, Xiangjiang</au><au>Yatsula, Bogdan</au><au>Xing, Ying</au><au>Fahmy, Tarek M</au><au>Dardik, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>38</volume><issue>1</issue><spage>195</spage><epage>205</epage><pages>195-205</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><abstract>Pseudoaneurysms remain a significant complication after vascular procedures. We hypothesized that TGF-β (transforming growth factor-β) signaling plays a mechanistic role in the development of pseudoaneurysms.
Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseudoaneurysms at 30 days, with increased smad2 phosphorylation in small pseudoaneurysms but not in large pseudoaneurysms; TGF-β1 receptors were increased in small pseudoaneurysms and preserved in large pseudoaneurysms. Delivery of TGF-β1 via nanoparticles covalently bonded to the patch stimulated smad2 phosphorylation both in vitro and in vivo and significantly decreased pseudoaneurysm formation (6.7%). Inhibition of TGF-β1 signaling with SB431542 decreased smad2 phosphorylation both in vitro and in vivo and significantly induced pseudoaneurysm formation by day 7 (66.7%).
Normal healing after aortic patch angioplasty is associated with increased TGF-β1 signaling, and recruitment of smad2 signaling may limit pseudoaneurysm formation; loss of TGF-β1 signaling is associated with the formation of large pseudoaneurysms. Enhancement of TGF-β1 signaling may be a potential mechanism to limit pseudoaneurysm formation after vascular intervention.</abstract><cop>United States</cop><pmid>29146747</pmid><doi>10.1161/ATVBAHA.117.310372</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2018-01, Vol.38 (1), p.195-205 |
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| language | eng |
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| subjects | Aneurysm, False - etiology Aneurysm, False - metabolism Aneurysm, False - pathology Aneurysm, False - prevention & control Angioplasty - adverse effects Angioplasty - instrumentation Animals Aorta - metabolism Aorta - pathology Aorta - surgery Aortic Aneurysm - etiology Aortic Aneurysm - metabolism Aortic Aneurysm - pathology Aortic Aneurysm - prevention & control Cells, Cultured Coated Materials, Biocompatible Male Mice Nanoparticles Pericardium - transplantation Phosphorylation Prosthesis Design Rats, Wistar Signal Transduction - drug effects Smad2 Protein - metabolism Time Factors Transforming Growth Factor beta1 - administration & dosage Wound Healing - drug effects |
| title | Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty |
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