Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus

•Up-regulating the expression of miR-146a can extend the latency to generalized convulsions and decrease seizure severity in the SE model.•MiR-146a may play a protective role by down-regulating the expression of IL-1β, TNF-α, TLR4 and NF-κB.•Regulating the expression level of miR-146a may provide a...

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