Workflow for Target‐Oriented Parametrization of an Enhanced Mechanistic Cell Culture Model

The goal of this study is to develop a macroscopic mechanistic model describing growth and production within fed‐batch cultivations of CHO cells. The model should be used for process characterization as well as for process monitoring including real‐time parameter adaptations. The model proved to be...

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Veröffentlicht in:	Biotechnology journal 2018-04, Vol.13 (4), p.e1700395-n/a
Hauptverfasser:	Ulonska, Sophia, Kroll, Paul, Fricke, Jens, Clemens, Christoph, Voges, Raphael, Müller, Markus M., Herwig, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Batch Cell Culture Techniques - methods bioprocess models CHO cells CHO Cells - cytology Cricetulus model analysis Models, Biological parameter identification Workflow
Online-Zugang:	Volltext
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