The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line

Summary The sirtuin 1/2 inhibitor tenovin-1 activates p53 and may have potential in the management of cancer. Here, we investigated the responsiveness of Ewing’s sarcoma cells to tenovin-1. We examined its effects in two Ewing’s sarcoma cell lines with different p53 status, i.e. in p53 wild-type and...

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Veröffentlicht in:	Investigational new drugs 2018-06, Vol.36 (3), p.396-406
Hauptverfasser:	Marx, Christian, Marx-Blümel, Lisa, Lindig, Nora, Thierbach, René, Hoelzer, Doerte, Becker, Sabine, Wittig, Susan, Lehmann, Roland, Slevogt, Hortense, Heinzel, Thorsten, Wang, Zhao-Qi, Beck, James F., Sonnemann, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Inducing Factor - metabolism Apoptosis-inducing factor Bcl-2 protein Caspase Caspase-3 Caspases - metabolism Cell death Cell Line, Tumor Deoxyribonucleic acid Depolarization DNA DNA Damage Ewings sarcoma Flow cytometry Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Immunoblotting Inhibitors Low concentrations Medicine Medicine & Public Health Membrane potential Mitochondria Mode of action Mortality Nonlinear response Nuclear transport Null cells Oncology p53 Protein Pharmacology/Toxicology Preclinical Studies Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Sarcoma Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - metabolism Sirtuin 2 - antagonists & inhibitors Sirtuin 2 - metabolism Thiourea - analogs & derivatives Thiourea - pharmacology Translocation Tumor cell lines Tumor Suppressor Protein p53 - metabolism
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