Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

The novel recombinant anthrax toxin, PrAgU2/FP59, composed of the urokinase-activated protective antigen and a fusion protein of Pseudomonas exotoxin and lethal factor was tested for anti-lung cancer efficacy in an in vivo human tumor model. Male athymic nude mice (age 4-6 weeks) were inoculated s.c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-04, Vol.67 (7), p.3329-3336
Hauptverfasser:	YUNPENG SU, ORTIZ, Janelle, SHIHUI LIU, BUGGE, Thomas H, SINGH, Ravibhushan, LEPPLA, Stephen H, FRANKEL, Arthur E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - pharmacology Antigens, Bacterial - toxicity Antineoplastic agents Bacterial diseases Bacterial Toxins - pharmacokinetics Bacterial Toxins - pharmacology Bacterial Toxins - toxicity Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - metabolism Dose-Response Relationship, Drug Exotoxins - pharmacokinetics Exotoxins - pharmacology Exotoxins - toxicity Human bacterial diseases Humans Infectious diseases Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - metabolism Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Miscellaneous Pharmacology. Drug treatments Pseudomonas Recombinant Fusion Proteins - pharmacokinetics Recombinant Fusion Proteins - pharmacology Recombinant Fusion Proteins - toxicity Tumors Urokinase-Type Plasminogen Activator - biosynthesis Urokinase-Type Plasminogen Activator - metabolism Xenograft Model Antitumor Assays
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