Mutation of the circadian clock gene per2 alters vascular endothelial function

The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Compared with the wild-type littermates, mice with Per2 mutation ex...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-04, Vol.115 (16), p.2188-2195
Hauptverfasser:	VISWAMBHARAN, Hema, CARVAS, Joao M, ANTIC, Vladan, MARECIC, Ana, JUD, Corinne, ZAUGG, Christian E, MING, Xiu-Fen, MONTANI, Jean-Pierre, ALBRECHT, Urs, ZHIHONG YANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adenosine Triphosphate - pharmacology Animals Antioxidants - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - physiopathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Glucose - analysis Blood Pressure Blood vessels and receptors Cardiology. Vascular system Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Circadian Rhythm - genetics Circadian Rhythm - radiation effects Cyclooxygenase 1 - biosynthesis Cyclooxygenase 1 - genetics Cyclooxygenase 1 - physiology Cyclooxygenase Inhibitors - pharmacology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Indomethacin - pharmacology Ionomycin - toxicity Lipids - blood Male Medical sciences Mice Mice, Knockout NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - deficiency Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type III Nitroprusside - pharmacology Nuclear Proteins - genetics Nuclear Proteins - physiology Period Circadian Proteins Receptor, Muscarinic M3 - biosynthesis Receptor, Muscarinic M3 - genetics Transcription Factors - genetics Transcription Factors - physiology Vasodilation - drug effects Vasodilation - physiology Vertebrates: cardiovascular system
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