Meningococcal polysaccharide vaccines: A review
Polysaccharides produced by Neisseria meningitidis are pharmaceutically important molecules, and are the active components of vaccines against N. meningitidis serogroups A, C, W135 and Y. Effective vaccines based on capsular polysaccharide, polysaccharide conjugates and outer membrane vesicles have...
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| Veröffentlicht in: | Carbohydrate polymers 2009-02, Vol.75 (4), p.553-565 |
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| container_title | Carbohydrate polymers |
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| creator | Joshi, Varsha S. Bajaj, Ishwar B. Survase, Shrikant A. Singhal, Rekha S. Kennedy, John F. |
| description | Polysaccharides produced by
Neisseria meningitidis are pharmaceutically important molecules, and are the active components of vaccines against
N. meningitidis serogroups A, C, W135 and Y. Effective vaccines based on capsular polysaccharide, polysaccharide conjugates and outer membrane vesicles have been developed for strains expressing capsular polysaccharides that define the sero groups A, C, Y and W135. However, conventional approaches to develop a vaccine for group B strains have been largely unsuccessful. This review focuses on the various aspects of fermentative production of meningococcal polysaccharide from
N. meningitidis, methods of conjugation for improving the immunogenicity of polysaccharide vaccine, and efficient and cost effective methods for the purification of
N. meningitidis capsular polysaccharide and outer membrane vesicles. In addition, different analytical techniques for the quantitative determination of polysaccharide vaccine and evaluation of structural integrity of conjugate vaccine have been described. |
| doi_str_mv | 10.1016/j.carbpol.2008.09.032 |
| format | Article |
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Neisseria meningitidis are pharmaceutically important molecules, and are the active components of vaccines against
N. meningitidis serogroups A, C, W135 and Y. Effective vaccines based on capsular polysaccharide, polysaccharide conjugates and outer membrane vesicles have been developed for strains expressing capsular polysaccharides that define the sero groups A, C, Y and W135. However, conventional approaches to develop a vaccine for group B strains have been largely unsuccessful. This review focuses on the various aspects of fermentative production of meningococcal polysaccharide from
N. meningitidis, methods of conjugation for improving the immunogenicity of polysaccharide vaccine, and efficient and cost effective methods for the purification of
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Neisseria meningitidis are pharmaceutically important molecules, and are the active components of vaccines against
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N. meningitidis, methods of conjugation for improving the immunogenicity of polysaccharide vaccine, and efficient and cost effective methods for the purification of
N. meningitidis capsular polysaccharide and outer membrane vesicles. In addition, different analytical techniques for the quantitative determination of polysaccharide vaccine and evaluation of structural integrity of conjugate vaccine have been described.</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Bacterial meningitis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Human bacterial diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Neisseria meningitidis</subject><subject>Outer membrane vesicle</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharide conjugate vaccines</subject><subject>Polysaccharide vaccines</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Specific populations (family, woman, child, elderly...)</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkM1OwzAQhC0EEqXwCEi5wC3p2rGdhAuqKv6kIi5wtpzNBlylSbHbor49rlpxZS-7h5lZzcfYNYeMA9eTRYbW16uhywRAmUGVQS5O2IiXRZXyXMpTNgIuZVpqXpyzixAWEEdzGLHJK_Wu_xxwQLRdEkN2wSJ-We8aSrbxdD2Fu2SaeNo6-rlkZ63tAl0d95h9PD68z57T-dvTy2w6T1Hmep2qthGlEkilqqQqi0YVVouyQQXEhcZSFZJsK7HWNSrkhQaJVdXWtQCrG8rH7PaQu_LD94bC2ixdQOo629OwCYZXWhUCdBSqgxD9EIKn1qy8W1q_MxzMHo9ZmCMes8djoDIRT_TdHB_YEJu33vbowp9ZcJFzATzq7g86im0jAW8COuqRGucJ16YZ3D-ffgFrAn0b</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Joshi, Varsha S.</creator><creator>Bajaj, Ishwar B.</creator><creator>Survase, Shrikant A.</creator><creator>Singhal, Rekha S.</creator><creator>Kennedy, John F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090201</creationdate><title>Meningococcal polysaccharide vaccines: A review</title><author>Joshi, Varsha S. ; Bajaj, Ishwar B. ; Survase, Shrikant A. ; Singhal, Rekha S. ; Kennedy, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-5fd2852ce8594587d57a628dc50e126c8574eaf4cb6bc5c17604c99fbb20a6de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Bacterial meningitis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Human bacterial diseases</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Neisseria meningitidis</topic><topic>Outer membrane vesicle</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharide conjugate vaccines</topic><topic>Polysaccharide vaccines</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Specific populations (family, woman, child, elderly...)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joshi, Varsha S.</creatorcontrib><creatorcontrib>Bajaj, Ishwar B.</creatorcontrib><creatorcontrib>Survase, Shrikant A.</creatorcontrib><creatorcontrib>Singhal, Rekha S.</creatorcontrib><creatorcontrib>Kennedy, John F.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joshi, Varsha S.</au><au>Bajaj, Ishwar B.</au><au>Survase, Shrikant A.</au><au>Singhal, Rekha S.</au><au>Kennedy, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meningococcal polysaccharide vaccines: A review</atitle><jtitle>Carbohydrate polymers</jtitle><date>2009-02-01</date><risdate>2009</risdate><volume>75</volume><issue>4</issue><spage>553</spage><epage>565</epage><pages>553-565</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>Polysaccharides produced by
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N. meningitidis, methods of conjugation for improving the immunogenicity of polysaccharide vaccine, and efficient and cost effective methods for the purification of
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| ispartof | Carbohydrate polymers, 2009-02, Vol.75 (4), p.553-565 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Bacterial meningitis Biological and medical sciences General pharmacology Human bacterial diseases Infectious diseases Medical sciences Neisseria meningitidis Outer membrane vesicle Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polysaccharide conjugate vaccines Polysaccharide vaccines Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Specific populations (family, woman, child, elderly...) |
| title | Meningococcal polysaccharide vaccines: A review |
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