A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia
Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms...
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| Veröffentlicht in: | Leukemia 2007-04, Vol.21 (4), p.647-650 |
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| creator | Marinelli, A Bossi, D Pelicci, P G Minucci, S |
| description | Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARbeta and RARgamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARalpha locus in leukemia patients must occur--rather than through functional differences among the various RAR isoforms-as the consequence of the nuclear architecture of the different RAR loci. |
| doi_str_mv | 10.1038/sj.leu.2404572 |
| format | Article |
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| ispartof | Leukemia, 2007-04, Vol.21 (4), p.647-650 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Acute promyeloid leukemia Animals Biological properties Cell Line Chromosome translocations Humans Isoforms Leukemia Leukemia, Promyelocytic, Acute - genetics Loci Mice Promyeloid leukemia Protein Isoforms - genetics Proteins Receptors Receptors, Retinoic Acid - genetics Retinoic acid Retinoic Acid Receptor alpha Retinoic Acid Receptor gamma Retinoic acid receptors RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Transfection Translocation, Genetic |
| title | A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia |
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