Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

Purpose: The programmed death-1 ligand/programmed death-1 (PD-L/PD-1) pathway has been recently suggested to play a pivotal role in the immune evasion of tumors from host immune system. In this study, we tried to reveal the clinical importance and therapeutic potential of the PD-L/PD-1 pathway in pa...

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Veröffentlicht in:	Clinical cancer research 2007-04, Vol.13 (7), p.2151-2157
Hauptverfasser:	NOMI, Takeo, SHO, Masayuki, NAKAJIMA, Yoshiyuki, AKAHORI, Takahiro, HAMADA, Kaoru, KUBO, Atsushi, KANEHIRO, Hiromichi, NAKAMURA, Shinji, ENOMOTO, Koji, YAGITA, Hideo, AZUMA, Miyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged Animals Antibodies, Monoclonal - pharmacology Antigens, CD - drug effects Antigens, CD - metabolism Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology B7-H1 B7-H1 Antigen Biological and medical sciences Biomarkers, Tumor - analysis CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Immunotherapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Male Medical sciences Mice Mice, Inbred C57BL Middle Aged Pancreas Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology PD-1 PD-1 Ligand Peptides - metabolism Pharmacology. Drug treatments Prognosis Programmed Cell Death 1 Ligand 2 Protein Reverse Transcriptase Polymerase Chain Reaction Tumors
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