Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment

The inositol polyphosphate 5′-phosphatase E (INPP5E) localizes to cilia. We showed that the carrier protein phosphodiesterase 6 delta subunit (PDE6δ) mediates the sorting of farnesylated INPP5E into cilia due to high affinity binding and release by the ADP-ribosylation factor (Arf)-like protein Arl3...

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Veröffentlicht in:	Biological chemistry 2018-02, Vol.399 (3), p.277-292
Hauptverfasser:	Kösling, Stefanie Kristine, Fansa, Eyad Kalawy, Maffini, Stefano, Wittinghofer, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate ADP-ribosylation factor Affinity Animals Arl3 Cells, Cultured Centrioles Cilia Cilia - metabolism cilium Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism Diffusion Dynein Dyneins - metabolism farnesylation Fluorescence Fluorescence microscopy Fluorescence recovery after photobleaching FRAP Guanosine triphosphate Inositol polyphosphate Joubert syndrome Localization Mice Microscopy, Fluorescence Mutants PDE6δ Phosphodiesterase Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Photobleaching Proteins Transport Transportation systems
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