TNF-α Polymorphisms in Chronic Beryllium Disease and Beryllium Sensitization

Objective: Tumor necrosis factor-alpha (TNF-α) is a potent cytokine involved in normal immune functions. The aim of this study was to investigate if there is an association between chronic beryllium disease or beryllium sensitization and two variants of the TNF-α gene located at -308 and -238 called...

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Veröffentlicht in:	Journal of occupational and environmental medicine 2007-04, Vol.49 (4), p.446-452
Hauptverfasser:	McCanlies, Erin C., Schuler, Christine R., Kreiss, Kathleen, Frye, Bonnie L., Ensey, James S., Weston, Ainsley
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Berylliosis - genetics Berylliosis - immunology Beryllium - blood Beryllium - immunology Beryllium - toxicity Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chronic Disease Genotype HLA-DP Antigens - genetics HLA-DP beta-Chains Humans Hypersensitivity - etiology Hypersensitivity - genetics Lymphocyte Activation Medical sciences Metals and various inorganic compounds Occupational Exposure - adverse effects ORIGINAL ARTICLES Polymorphism, Genetic Risk Factors Sequence Analysis, Protein Toxicology Tumor Necrosis Factor-alpha - chemistry Tumor Necrosis Factor-alpha - genetics United States
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