Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients

Atypical antipsychotics induce pre-diabetic symptoms in some but not all patients, characterized most notably by elevated weight. The side effect profiles of the various drugs in the class differ, however, raising the possibility of drug-specific mechanisms for similar side effects. We used physioge...

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Veröffentlicht in:	Molecular psychiatry 2007-05, Vol.12 (5), p.474-482
Hauptverfasser:	Ruaño, G, Goethe, J W, Caley, C, Woolley, S, Holford, T R, Kocherla, M, Windemuth, A, Leon, J de
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Analysis of Variance Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Antipsychotic drugs Antipsychotics Apolipoprotein E Apolipoproteins Apolipoproteins - drug effects Apolipoproteins - genetics Appetite Appetite Regulation - drug effects Appetite Regulation - genetics Aryldialkylphosphatase - drug effects Aryldialkylphosphatase - genetics Behavioral Sciences Benzodiazepines - adverse effects Benzodiazepines - therapeutic use Biological and medical sciences Biological Psychology Comparative analysis Complications and side effects Cross-Sectional Studies Diabetes mellitus Diseases Dosage and administration Drug therapy Female Genomics - methods Homeostasis Humans Lipid Metabolism - drug effects Lipid Metabolism - genetics Male Medical examination Medical sciences Medicine Medicine & Public Health Mental Disorders - drug therapy Metabolic diseases Middle Aged Neuropeptide Y Neuropharmacology Neurosciences Obesity Olanzapine original-article Overweight persons Paraoxonase Paraoxonase 1 Pharmacology. Drug treatments Pharmacotherapy Polymorphism, Single Nucleotide - genetics Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychological aspects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Receptors, Cell Surface - drug effects Receptors, Cell Surface - genetics Receptors, Leptin Receptors, Neuropeptide Y - drug effects Receptors, Neuropeptide Y - genetics Risk factors Risperidone Risperidone - adverse effects Risperidone - therapeutic use Scavenger receptors Scavenger Receptors, Class B - drug effects Scavenger Receptors, Class B - genetics Side effects Single-nucleotide polymorphism Weight Gain - drug effects Weight Gain - genetics
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