RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell

Alternative splicing (AS) of pre-messenger (m)RNA is a pivotal mechanism in expanding proteomic diversity, which determines the functions of mammalian cells. By conducting transcriptome analyses to profile splicing events in human colorectal cancer (CRC) tissues compared to adjacent normal counterpa...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2018-02, Vol.1865 (2), p.259-272
Hauptverfasser:	Lin, Jung-Chun, Lee, Yuan-Chii, Tan, Tse-Hua, Liang, Yu-Chih, Chuang, Huai-Chia, Fann, Yang C., Johnson, Kory R., Lin, Ying-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Female Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male MAP Kinase Signaling System MAP4K4 Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RBM4 RNA Splicing RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Serine-Arginine Splicing Factors - genetics Serine-Arginine Splicing Factors - metabolism SRSF3
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