A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells

•SG1 ameliorates OA-induced steatosis in HepG2 cell.•SG1 inhibits OA-induced Oxidative Stress in HepG2 cell.•The effect is probably based on CYP2E1 inhibition and JNK/c-jun dephosphorylation. Loquat (Eriobotrya japonica) leaf has displayed beneficial effect on metabolic syndrome. In our previously s...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-01, Vol.97, p.1125-1130
Hauptverfasser:	Jian, Tunyu, Wu, Yuexian, Ding, Xiaoqin, Lv, Han, Ma, Li, Zuo, Yuanyuan, Ren, Bingru, Zhao, Lei, Tong, Bei, Chen, Jian, Li, Weilin
Format:	Artikel
Sprache:	eng
Schlagworte:	c-jun terminal kinase Cholesterol - metabolism Cytochrome P-450 CYP2E1 - genetics Cytochrome P450 2E1 Dose-Response Relationship, Drug Down-Regulation - drug effects Eriobotrya - chemistry Fatty Acids, Nonesterified - metabolism Glycosides - administration & dosage Glycosides - isolation & purification Glycosides - pharmacology Hep G2 Cells Humans Loquat (Eriobotrya japonica) leaf Malondialdehyde - metabolism Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - pathology Oleic Acid - toxicity Oxidative Stress - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves Sesquiterpene glycoside Sesquiterpenes - administration & dosage Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Superoxide Dismutase - metabolism Triglycerides - metabolism
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