Assessment of hard target modeling in CASP12 reveals an emerging role of alignment‐based contact prediction methods

We present our assessment of CASP12 modeling efforts for targets with no obvious templates of high sequence/structure similarity in the PDB, that is for evaluation units of the free modeling (FM) and free modeling/template‐based modeling (FM/TBM) categories. Models were clustered and ranked using th...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2018-03, Vol.86 (S1), p.97-112
Hauptverfasser:	Abriata, Luciano A., Tamò, Giorgio E., Monastyrskyy, Bohdan, Kryshtafovych, Andriy, Dal Peraro, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Computational Biology - methods contact prediction critical assessment of structure prediction Crystallography, X-Ray Databases, Protein homology modeling Humans Inspection Mathematical models Modelling Models, Molecular Next-generation sequencing Protein Conformation Protein Folding Protein structure Proteins - chemistry residue coevolution Sequence Alignment Sequence Analysis, Protein Sequences structural bioinformatics Tertiary structure Topology
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