Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid‐resistant tuberculosis
: The management of patients with pre‐existing tuberculosis (TB) undergoing liver transplantation is challenging. Cautious immunosuppression is required to prevent reactivation of disease, and second‐line anti‐tuberculous treatment may be necessary to prevent graft hepatotoxicity. Furthermore, liver...
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| Veröffentlicht in: | Transplant infectious disease 2008-08, Vol.10 (4), p.272-275 |
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| container_title | Transplant infectious disease |
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| creator | Nash, K.L. Yeung, T.M. Lehner, P.J. Gibbs, P. Griffiths, W.J.H. |
| description | : The management of patients with pre‐existing tuberculosis (TB) undergoing liver transplantation is challenging. Cautious immunosuppression is required to prevent reactivation of disease, and second‐line anti‐tuberculous treatment may be necessary to prevent graft hepatotoxicity. Furthermore, liver transplantation in the context of isoniazid‐resistant TB has seldom been reported. We report on a 44‐year‐old man with recent isoniazid‐resistant extra‐pulmonary TB who developed subacute hepatic failure requiring emergency liver transplantation and treatment with second‐line anti‐tuberculous therapy. We demonstrate that patients who have pre‐existing TB can be successfully treated with alternative anti‐tuberculous medication while under immunosuppression post transplantation. Pre‐existing TB, including resistant strains, should not be an absolute contraindication to liver transplantation. |
| doi_str_mv | 10.1111/j.1399-3062.2007.00277.x |
| format | Article |
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Cautious immunosuppression is required to prevent reactivation of disease, and second‐line anti‐tuberculous treatment may be necessary to prevent graft hepatotoxicity. Furthermore, liver transplantation in the context of isoniazid‐resistant TB has seldom been reported. We report on a 44‐year‐old man with recent isoniazid‐resistant extra‐pulmonary TB who developed subacute hepatic failure requiring emergency liver transplantation and treatment with second‐line anti‐tuberculous therapy. We demonstrate that patients who have pre‐existing TB can be successfully treated with alternative anti‐tuberculous medication while under immunosuppression post transplantation. Pre‐existing TB, including resistant strains, should not be an absolute contraindication to liver transplantation.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/j.1399-3062.2007.00277.x</identifier><identifier>PMID: 17868274</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Antitubercular Agents - adverse effects ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; Drug Resistance, Bacterial ; failure ; Humans ; Isoniazid - adverse effects ; Isoniazid - pharmacology ; Isoniazid - therapeutic use ; isoniazid resistant ; liver ; Liver Failure, Acute - chemically induced ; Liver Failure, Acute - surgery ; Liver Transplantation ; Male ; Mycobacterium ; Mycobacterium tuberculosis - drug effects ; transplantation ; Treatment Outcome ; tuberculosis ; Tuberculosis, Lymph Node - drug therapy ; Tuberculosis, Lymph Node - microbiology</subject><ispartof>Transplant infectious disease, 2008-08, Vol.10 (4), p.272-275</ispartof><rights>2008 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3977-e5b7c82709a9cbb55feeef87f28142078da3ea834f2865999557a96f195a95f3</citedby><cites>FETCH-LOGICAL-c3977-e5b7c82709a9cbb55feeef87f28142078da3ea834f2865999557a96f195a95f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3062.2007.00277.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3062.2007.00277.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17868274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nash, K.L.</creatorcontrib><creatorcontrib>Yeung, T.M.</creatorcontrib><creatorcontrib>Lehner, P.J.</creatorcontrib><creatorcontrib>Gibbs, P.</creatorcontrib><creatorcontrib>Griffiths, W.J.H.</creatorcontrib><title>Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid‐resistant tuberculosis</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>: The management of patients with pre‐existing tuberculosis (TB) undergoing liver transplantation is challenging. Cautious immunosuppression is required to prevent reactivation of disease, and second‐line anti‐tuberculous treatment may be necessary to prevent graft hepatotoxicity. Furthermore, liver transplantation in the context of isoniazid‐resistant TB has seldom been reported. We report on a 44‐year‐old man with recent isoniazid‐resistant extra‐pulmonary TB who developed subacute hepatic failure requiring emergency liver transplantation and treatment with second‐line anti‐tuberculous therapy. We demonstrate that patients who have pre‐existing TB can be successfully treated with alternative anti‐tuberculous medication while under immunosuppression post transplantation. Pre‐existing TB, including resistant strains, should not be an absolute contraindication to liver transplantation.</description><subject>Adult</subject><subject>Antitubercular Agents - adverse effects</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Drug Resistance, Bacterial</subject><subject>failure</subject><subject>Humans</subject><subject>Isoniazid - adverse effects</subject><subject>Isoniazid - pharmacology</subject><subject>Isoniazid - therapeutic use</subject><subject>isoniazid resistant</subject><subject>liver</subject><subject>Liver Failure, Acute - chemically induced</subject><subject>Liver Failure, Acute - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>transplantation</subject><subject>Treatment Outcome</subject><subject>tuberculosis</subject><subject>Tuberculosis, Lymph Node - drug therapy</subject><subject>Tuberculosis, Lymph Node - microbiology</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u3CAUhVHUKJn8vELFqjs7YGxjpG6q6U8iRcpm9ggzl4QRY1zAnUk27SPkGfMkZTKjZBs2XJ177rnwIYQpKWk-V6uSMiEKRtqqrAjhJSEV5-X2CM3eGp9e666oKs5O0VmMK0IoF7U4QaeUd21X8XqG_t6F9OCTH63Gzv6BgFNQQxydGpJK1g_Y-IDj1Cs9JcAPMGZVY6OsmwLkpnN-Y4d7PKqQrHJ5HFRaw5CwN9hGP1j1ZJcv_54DRBtTjsVp6iHoyfksXKBjo1yEy8N9jhY_fyzm18Xt3a-b-bfbQjPBeQFNz3V-MRFK6L5vGgMApuOm6mhdEd4tFQPVsToLbSOEaBquRGuoaJRoDDtHX_axY_C_J4hJrm3U4PI3wU9RUtHWjLA6G7u9UQcfYwAjx2DXKjxKSuSOvVzJHWK5Qyx37OUre7nNo58PO6Z-Dcv3wQPsbPi6N2ysg8cPB8vFzfdcsP-1iZfH</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Nash, K.L.</creator><creator>Yeung, T.M.</creator><creator>Lehner, P.J.</creator><creator>Gibbs, P.</creator><creator>Griffiths, W.J.H.</creator><general>Blackwell Publishing Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>200808</creationdate><title>Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid‐resistant tuberculosis</title><author>Nash, K.L. ; Yeung, T.M. ; Lehner, P.J. ; Gibbs, P. ; Griffiths, W.J.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3977-e5b7c82709a9cbb55feeef87f28142078da3ea834f2865999557a96f195a95f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Antitubercular Agents - adverse effects</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Drug Resistance, Bacterial</topic><topic>failure</topic><topic>Humans</topic><topic>Isoniazid - adverse effects</topic><topic>Isoniazid - pharmacology</topic><topic>Isoniazid - therapeutic use</topic><topic>isoniazid resistant</topic><topic>liver</topic><topic>Liver Failure, Acute - chemically induced</topic><topic>Liver Failure, Acute - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>transplantation</topic><topic>Treatment Outcome</topic><topic>tuberculosis</topic><topic>Tuberculosis, Lymph Node - drug therapy</topic><topic>Tuberculosis, Lymph Node - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nash, K.L.</creatorcontrib><creatorcontrib>Yeung, T.M.</creatorcontrib><creatorcontrib>Lehner, P.J.</creatorcontrib><creatorcontrib>Gibbs, P.</creatorcontrib><creatorcontrib>Griffiths, W.J.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nash, K.L.</au><au>Yeung, T.M.</au><au>Lehner, P.J.</au><au>Gibbs, P.</au><au>Griffiths, W.J.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid‐resistant tuberculosis</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2008-08</date><risdate>2008</risdate><volume>10</volume><issue>4</issue><spage>272</spage><epage>275</epage><pages>272-275</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>: The management of patients with pre‐existing tuberculosis (TB) undergoing liver transplantation is challenging. Cautious immunosuppression is required to prevent reactivation of disease, and second‐line anti‐tuberculous treatment may be necessary to prevent graft hepatotoxicity. Furthermore, liver transplantation in the context of isoniazid‐resistant TB has seldom been reported. We report on a 44‐year‐old man with recent isoniazid‐resistant extra‐pulmonary TB who developed subacute hepatic failure requiring emergency liver transplantation and treatment with second‐line anti‐tuberculous therapy. We demonstrate that patients who have pre‐existing TB can be successfully treated with alternative anti‐tuberculous medication while under immunosuppression post transplantation. Pre‐existing TB, including resistant strains, should not be an absolute contraindication to liver transplantation.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17868274</pmid><doi>10.1111/j.1399-3062.2007.00277.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transplant infectious disease, 2008-08, Vol.10 (4), p.272-275 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antitubercular Agents - adverse effects Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Drug Resistance, Bacterial failure Humans Isoniazid - adverse effects Isoniazid - pharmacology Isoniazid - therapeutic use isoniazid resistant liver Liver Failure, Acute - chemically induced Liver Failure, Acute - surgery Liver Transplantation Male Mycobacterium Mycobacterium tuberculosis - drug effects transplantation Treatment Outcome tuberculosis Tuberculosis, Lymph Node - drug therapy Tuberculosis, Lymph Node - microbiology |
| title | Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid‐resistant tuberculosis |
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