Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study
Purpose To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study. Methods Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) se...
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| Veröffentlicht in: | International urology and nephrology 2018-03, Vol.50 (3), p.527-534 |
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| creator | Fuhro, Maria Isabel Dorneles, Gilson P. Andrade, Francini P. Romão, Pedro R. T. Peres, Alessandra Monteiro, Mariane B. |
| description | Purpose
To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study.
Methods
Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56
bright
and CD3-CD56
dim
), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels.
Results
HD therapy induced a significant decrease in NK cells frequency (
p
= 0.039), NK CD3-CD56
bright
cells (
p
= 0.04), and CD3-CD56
dim
cells (
p
= 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (
p
> 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (
p
> 0.05). However, HD therapy increased cortisol concentrations after HD therapy (
p
= 0.034).
Conclusions
This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy. |
| doi_str_mv | 10.1007/s11255-017-1747-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1964273452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1964273452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-590c789c3a39369919a05a37bb3a9047367ffa2b2e231965b65ea479c28b5d453</originalsourceid><addsrcrecordid>eNp1kctqGzEUhkVJqZ2kD5BNEGTTzTS6jqzsTGguYMimWQuN5riWM56ZSpq0zgv0taOxnVIKWQnE9__ncD6Ezij5SglRl5FSJmVBqCqoEqp4-YCmVCpeMDkTR2hKOKEFLRmfoOMY14QQPSPkE5owTbkoqZiiP3M3JMDwG4LzEXA9BN_-wCvYdLW3zTb6iPsAz9CmiNMqA-AC2Ez6Frc2DcE2-Mk3DQTsoGni-N_b5HeBXz6tsFuFrvUuU3ULW1znMTl_hS3ufdMlHNNQb0_Rx6VtInw-vCfo8ebb9-u7YvFwe389XxSOK5YKqYlTM-245ZqXWlNtibRcVRW3mgjFS7VcWlYxYJzqUlalBCuUdmxWyVpIfoK-7Hv70P0cICaz8XFc3LbQDdHkkGCKC8kyevEfuu6G0ObtRorn28odRfeUC12MAZamD35jw9ZQYkZLZm_JZEtmtGRecub80DxUG6j_Jt60ZIDtgdiPOiD8M_rd1lezAJ6B</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963301552</pqid></control><display><type>article</type><title>Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study</title><source>SpringerNature Journals</source><creator>Fuhro, Maria Isabel ; Dorneles, Gilson P. ; Andrade, Francini P. ; Romão, Pedro R. T. ; Peres, Alessandra ; Monteiro, Mariane B.</creator><creatorcontrib>Fuhro, Maria Isabel ; Dorneles, Gilson P. ; Andrade, Francini P. ; Romão, Pedro R. T. ; Peres, Alessandra ; Monteiro, Mariane B.</creatorcontrib><description>Purpose
To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study.
Methods
Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56
bright
and CD3-CD56
dim
), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels.
Results
HD therapy induced a significant decrease in NK cells frequency (
p
= 0.039), NK CD3-CD56
bright
cells (
p
= 0.04), and CD3-CD56
dim
cells (
p
= 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (
p
> 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (
p
> 0.05). However, HD therapy increased cortisol concentrations after HD therapy (
p
= 0.034).
Conclusions
This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-017-1747-z</identifier><identifier>PMID: 29134614</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>C-reactive protein ; CD3 antigen ; Cortisol ; Creatine ; Creatine kinase ; Creatinine ; Hemodialysis ; Kidney diseases ; Kidney transplantation ; Kinases ; Medicine ; Medicine & Public Health ; Natural killer cells ; Nephrology ; Nephrology - Original Paper ; Peripheral blood ; Urea ; Urology</subject><ispartof>International urology and nephrology, 2018-03, Vol.50 (3), p.527-534</ispartof><rights>Springer Science+Business Media B.V., part of Springer Nature 2017</rights><rights>International Urology and Nephrology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-590c789c3a39369919a05a37bb3a9047367ffa2b2e231965b65ea479c28b5d453</citedby><cites>FETCH-LOGICAL-c372t-590c789c3a39369919a05a37bb3a9047367ffa2b2e231965b65ea479c28b5d453</cites><orcidid>0000-0001-6524-3204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-017-1747-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-017-1747-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29134614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuhro, Maria Isabel</creatorcontrib><creatorcontrib>Dorneles, Gilson P.</creatorcontrib><creatorcontrib>Andrade, Francini P.</creatorcontrib><creatorcontrib>Romão, Pedro R. T.</creatorcontrib><creatorcontrib>Peres, Alessandra</creatorcontrib><creatorcontrib>Monteiro, Mariane B.</creatorcontrib><title>Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study.
Methods
Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56
bright
and CD3-CD56
dim
), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels.
Results
HD therapy induced a significant decrease in NK cells frequency (
p
= 0.039), NK CD3-CD56
bright
cells (
p
= 0.04), and CD3-CD56
dim
cells (
p
= 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (
p
> 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (
p
> 0.05). However, HD therapy increased cortisol concentrations after HD therapy (
p
= 0.034).
Conclusions
This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.</description><subject>C-reactive protein</subject><subject>CD3 antigen</subject><subject>Cortisol</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Creatinine</subject><subject>Hemodialysis</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Natural killer cells</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Peripheral blood</subject><subject>Urea</subject><subject>Urology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctqGzEUhkVJqZ2kD5BNEGTTzTS6jqzsTGguYMimWQuN5riWM56ZSpq0zgv0taOxnVIKWQnE9__ncD6Ezij5SglRl5FSJmVBqCqoEqp4-YCmVCpeMDkTR2hKOKEFLRmfoOMY14QQPSPkE5owTbkoqZiiP3M3JMDwG4LzEXA9BN_-wCvYdLW3zTb6iPsAz9CmiNMqA-AC2Ez6Frc2DcE2-Mk3DQTsoGni-N_b5HeBXz6tsFuFrvUuU3ULW1znMTl_hS3ufdMlHNNQb0_Rx6VtInw-vCfo8ebb9-u7YvFwe389XxSOK5YKqYlTM-245ZqXWlNtibRcVRW3mgjFS7VcWlYxYJzqUlalBCuUdmxWyVpIfoK-7Hv70P0cICaz8XFc3LbQDdHkkGCKC8kyevEfuu6G0ObtRorn28odRfeUC12MAZamD35jw9ZQYkZLZm_JZEtmtGRecub80DxUG6j_Jt60ZIDtgdiPOiD8M_rd1lezAJ6B</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Fuhro, Maria Isabel</creator><creator>Dorneles, Gilson P.</creator><creator>Andrade, Francini P.</creator><creator>Romão, Pedro R. T.</creator><creator>Peres, Alessandra</creator><creator>Monteiro, Mariane B.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6524-3204</orcidid></search><sort><creationdate>20180301</creationdate><title>Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study</title><author>Fuhro, Maria Isabel ; Dorneles, Gilson P. ; Andrade, Francini P. ; Romão, Pedro R. T. ; Peres, Alessandra ; Monteiro, Mariane B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-590c789c3a39369919a05a37bb3a9047367ffa2b2e231965b65ea479c28b5d453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>C-reactive protein</topic><topic>CD3 antigen</topic><topic>Cortisol</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Creatinine</topic><topic>Hemodialysis</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Kinases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Natural killer cells</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Peripheral blood</topic><topic>Urea</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuhro, Maria Isabel</creatorcontrib><creatorcontrib>Dorneles, Gilson P.</creatorcontrib><creatorcontrib>Andrade, Francini P.</creatorcontrib><creatorcontrib>Romão, Pedro R. T.</creatorcontrib><creatorcontrib>Peres, Alessandra</creatorcontrib><creatorcontrib>Monteiro, Mariane B.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuhro, Maria Isabel</au><au>Dorneles, Gilson P.</au><au>Andrade, Francini P.</au><au>Romão, Pedro R. T.</au><au>Peres, Alessandra</au><au>Monteiro, Mariane B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>50</volume><issue>3</issue><spage>527</spage><epage>534</epage><pages>527-534</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study.
Methods
Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56
bright
and CD3-CD56
dim
), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels.
Results
HD therapy induced a significant decrease in NK cells frequency (
p
= 0.039), NK CD3-CD56
bright
cells (
p
= 0.04), and CD3-CD56
dim
cells (
p
= 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (
p
> 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (
p
> 0.05). However, HD therapy increased cortisol concentrations after HD therapy (
p
= 0.034).
Conclusions
This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29134614</pmid><doi>10.1007/s11255-017-1747-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6524-3204</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-1623 |
| ispartof | International urology and nephrology, 2018-03, Vol.50 (3), p.527-534 |
| issn | 0301-1623 1573-2584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1964273452 |
| source | SpringerNature Journals |
| subjects | C-reactive protein CD3 antigen Cortisol Creatine Creatine kinase Creatinine Hemodialysis Kidney diseases Kidney transplantation Kinases Medicine Medicine & Public Health Natural killer cells Nephrology Nephrology - Original Paper Peripheral blood Urea Urology |
| title | Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study |
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