Synthesis of bis-indolylmethanes as new potential inhibitors of β-glucuronidase and their molecular docking studies

Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1–32 were synthesized and characterized by 1HNMR, 13CNNMR and HREI-MS. All compounds were evaluated in vitro for β-glucuronidase inhibitory potential. All analogs showed varying degree of β-glucuronidase inhibitory potential ranging from 0.10 ± 0....

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Veröffentlicht in:	European journal of medicinal chemistry 2018-01, Vol.143, p.1757-1767
Hauptverfasser:	Taha, Muhammad, Ullah, Hayat, Al Muqarrabun, Laode Muhammad Ramadhan, Khan, Muhammad Naseem, Rahim, Fazal, Ahmat, Norizan, Ali, Muhammad, Perveen, Shahnaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Bis-indolylmethanes Dose-Response Relationship, Drug Glucuronidase - antagonists & inhibitors Glucuronidase - metabolism Glycoproteins - chemical synthesis Glycoproteins - chemistry Glycoproteins - pharmacology Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Molecular docking Molecular Docking Simulation Molecular Structure SAR Structure-Activity Relationship Synthesis β-Glucuronidase activity
Online-Zugang:	Volltext
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