Immunomodulation of dual specificity phosphatase 4 during visceral leishmaniasis

DUSP4, an inducible protein has a substrate specificity toward ERK1/2, a component of MAP kinase which is enhanced during Leishmania infection. The DUSP4−/− mice show increased susceptibility towards the infection caused by Toxoplasma gondii and Leishmania mexicana. These observations emphatically e...

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Veröffentlicht in:	Microbes and infection 2018-02, Vol.20 (2), p.111-121
Hauptverfasser:	Parveen, Shabina, Chowdhury, Atish Roy, Jawed, Junaid Jibran, Majumdar, Suchandra Bhattacharyya, Saha, Bhaskar, Majumdar, Subrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Cytokines - genetics DUSP4 Gene Expression Regulation - drug effects Glycyrrhizic Acid - administration & dosage Glycyrrhizic Acid - pharmacology Humans Immunologic Factors - administration & dosage Immunologic Factors - pharmacology Immunomodulation Leishmania Leishmania donovani - physiology Leishmaniasis, Visceral - enzymology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Macrophages - immunology Macrophages - parasitology Mice Mice, Inbred BALB C Nitric Oxide - analysis Phosphorylation - drug effects Protein Tyrosine Phosphatases - deficiency Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism RNA, Small Interfering - administration & dosage Th1 Cells - secretion Th2 Cells - secretion THP-1 Cells Visceral leishmaniasis
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