Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer

A series of novel amidino 2-substituted benzimidazoles linked to 1,4-disubstituted 1,2,3-triazoles were synthesized by implementation of microwave and ultrasound irradiation in click reaction and subsequent condensation of thus obtained 4-(1,2,3-triazol-1-yl)benzaldehyde with o-phenylenediamines. In...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-01, Vol.143, p.1616-1634
Hauptverfasser:	Bistrović, Andrea, Krstulović, Luka, Harej, Anja, Grbčić, Petra, Sedić, Mirela, Koštrun, Sanja, Pavelić, Sandra Kraljević, Bajić, Miroslav, Raić-Malić, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-triazole Benzimidazole Kinase Multitarget Non-small cell lung cancer (A549) p38 MAPK
Online-Zugang:	Volltext
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