locus encoding an oligomorphic family of MHC-A alleles (Mane-A06/Mamu-A05) is present at high frequency in several macaque species
Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. In this study, we demonstra...
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| Veröffentlicht in: | Immunogenetics (New York) 2007-03, Vol.59 (3), p.211-223 |
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| creator | Lafont, Bernard A. P McGraw, Christopher M Stukes, Sabriya A Buckler-White, Alicia Plishka, Ronald J Byrum, Russell A Hirsch, Vanessa M Martin, Malcolm A |
| description | Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. In this study, we demonstrate that the gene expressing the Mane-A*06 allele of pig-tailed macaques is an orthologue of the locus encoding the Mamu-A*05 allele family in rhesus macaques. Analysis of the distribution of this locus in a cohort of 63 pig-tailed macaques revealed that it encodes an oligomorphic family of alleles, highly prevalent (90%) in the pig-tailed macaque population. Similarly, this locus was very frequently found (62%) in a cohort of 80 Indian rhesus macaques. An orthologous gene was also detected in cynomolgus monkeys originating from four different geographical locations, but was absent in two African monkey species. Expression analysis in pig-tailed macaques revealed that the Mane-A*06 alleles encoded by this locus are transcribed at 10- to 20-fold lower levels than other MHC-A alleles (Mane-A*03 or Mane-A*10). Despite their conservation and high prevalence among Asian macaque species, the alleles of the Mane-A*06 family and, by extension their orthologues in rhesus and cynomolgus monkeys, may only modestly contribute to cellular immune responses in macaques because of their low level of expression. |
| doi_str_mv | 10.1007/s00251-007-0190-1 |
| format | Article |
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P ; McGraw, Christopher M ; Stukes, Sabriya A ; Buckler-White, Alicia ; Plishka, Ronald J ; Byrum, Russell A ; Hirsch, Vanessa M ; Martin, Malcolm A</creator><creatorcontrib>Lafont, Bernard A. P ; McGraw, Christopher M ; Stukes, Sabriya A ; Buckler-White, Alicia ; Plishka, Ronald J ; Byrum, Russell A ; Hirsch, Vanessa M ; Martin, Malcolm A</creatorcontrib><description>Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. In this study, we demonstrate that the gene expressing the Mane-A*06 allele of pig-tailed macaques is an orthologue of the locus encoding the Mamu-A*05 allele family in rhesus macaques. Analysis of the distribution of this locus in a cohort of 63 pig-tailed macaques revealed that it encodes an oligomorphic family of alleles, highly prevalent (90%) in the pig-tailed macaque population. Similarly, this locus was very frequently found (62%) in a cohort of 80 Indian rhesus macaques. An orthologous gene was also detected in cynomolgus monkeys originating from four different geographical locations, but was absent in two African monkey species. Expression analysis in pig-tailed macaques revealed that the Mane-A*06 alleles encoded by this locus are transcribed at 10- to 20-fold lower levels than other MHC-A alleles (Mane-A*03 or Mane-A*10). Despite their conservation and high prevalence among Asian macaque species, the alleles of the Mane-A*06 family and, by extension their orthologues in rhesus and cynomolgus monkeys, may only modestly contribute to cellular immune responses in macaques because of their low level of expression.</description><identifier>ISSN: 0093-7711</identifier><identifier>EISSN: 1432-1211</identifier><identifier>DOI: 10.1007/s00251-007-0190-1</identifier><identifier>PMID: 17256149</identifier><language>eng</language><publisher>United States: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Alleles ; Amino Acid Sequence ; Animals ; Base Sequence ; Cynomolgus ; Evolution, Molecular ; Gene Duplication ; Gene Frequency ; Genes, MHC Class I ; Human immunodeficiency virus ; Immune system ; Immunization ; Introns ; Locus ; Macaca - genetics ; Macaca mulatta ; Macaca nemestrina ; MHC class I ; Molecular Sequence Data ; Monkeys & apes ; Phylogeny ; Polymorphism, Genetic ; Sequence Homology, Amino Acid ; Site specific primer-PCR (SSP-PCR) ; Swine</subject><ispartof>Immunogenetics (New York), 2007-03, Vol.59 (3), p.211-223</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-4f34ac4ff6f03f52027a52d930fce74e25205bb2cb5f61b1f6717242cdc9c6cd3</citedby><cites>FETCH-LOGICAL-c393t-4f34ac4ff6f03f52027a52d930fce74e25205bb2cb5f61b1f6717242cdc9c6cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17256149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lafont, Bernard A. P</creatorcontrib><creatorcontrib>McGraw, Christopher M</creatorcontrib><creatorcontrib>Stukes, Sabriya A</creatorcontrib><creatorcontrib>Buckler-White, Alicia</creatorcontrib><creatorcontrib>Plishka, Ronald J</creatorcontrib><creatorcontrib>Byrum, Russell A</creatorcontrib><creatorcontrib>Hirsch, Vanessa M</creatorcontrib><creatorcontrib>Martin, Malcolm A</creatorcontrib><title>locus encoding an oligomorphic family of MHC-A alleles (Mane-A06/Mamu-A05) is present at high frequency in several macaque species</title><title>Immunogenetics (New York)</title><addtitle>Immunogenetics</addtitle><description>Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. 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Despite their conservation and high prevalence among Asian macaque species, the alleles of the Mane-A*06 family and, by extension their orthologues in rhesus and cynomolgus monkeys, may only modestly contribute to cellular immune responses in macaques because of their low level of expression.</description><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cynomolgus</subject><subject>Evolution, Molecular</subject><subject>Gene Duplication</subject><subject>Gene Frequency</subject><subject>Genes, MHC Class I</subject><subject>Human immunodeficiency virus</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Introns</subject><subject>Locus</subject><subject>Macaca - genetics</subject><subject>Macaca mulatta</subject><subject>Macaca nemestrina</subject><subject>MHC class I</subject><subject>Molecular Sequence Data</subject><subject>Monkeys & apes</subject><subject>Phylogeny</subject><subject>Polymorphism, Genetic</subject><subject>Sequence Homology, Amino Acid</subject><subject>Site specific primer-PCR (SSP-PCR)</subject><subject>Swine</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU-LFDEQxYMo7uzqB_CiwcOih7ip_GtyHAZ1hR086J5DOp3MZEl32mRamKuf3AwzIHiqR_GrV1U8hN4A_QSUdneVUiaBNEkoaErgGVqB4IwAA3iOVpRqTroO4Apd1_pEKUjN1Et0BR2TCoReoT8pu6ViP7k8xGmH7YRzirs85jLvo8PBjjEdcQ54e78ha2xT8slX_GFrJ0_WVN1t7bg0IT_iWPFcfPXTAdsD3sfdHofify3N_IjjhKv_7YtNeLTOti6us3fR11foRbCp-teXeoMev3z-ubknD9-_ftusH4jjmh-ICFxYJ0JQgfIgGWWdlWzQnAbnO-FZa8m-Z66XQUEPQXXtTcHc4LRTbuA36PbsO5fc1teDGWN1PqX2SV6qAa0EaC0b-P4_8CkvZWq3GcU6Bowr1SA4Q67kWosPZi5xtOVogJpTOuacjjnJUzoG2szbi_HSj374N3GJowHvzkCw2dhdidU8_mAUeDMRkgnO_wKmvpJ9</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Lafont, Bernard A. 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P</au><au>McGraw, Christopher M</au><au>Stukes, Sabriya A</au><au>Buckler-White, Alicia</au><au>Plishka, Ronald J</au><au>Byrum, Russell A</au><au>Hirsch, Vanessa M</au><au>Martin, Malcolm A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>locus encoding an oligomorphic family of MHC-A alleles (Mane-A06/Mamu-A05) is present at high frequency in several macaque species</atitle><jtitle>Immunogenetics (New York)</jtitle><addtitle>Immunogenetics</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>59</volume><issue>3</issue><spage>211</spage><epage>223</epage><pages>211-223</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><abstract>Several macaques species are used for HIV pathogenesis and vaccine studies, and the characterization of their major histocompatibility complex (MHC) class I genes is required to rigorously evaluate the cellular immune responses induced after immunization and/or infection. In this study, we demonstrate that the gene expressing the Mane-A*06 allele of pig-tailed macaques is an orthologue of the locus encoding the Mamu-A*05 allele family in rhesus macaques. Analysis of the distribution of this locus in a cohort of 63 pig-tailed macaques revealed that it encodes an oligomorphic family of alleles, highly prevalent (90%) in the pig-tailed macaque population. Similarly, this locus was very frequently found (62%) in a cohort of 80 Indian rhesus macaques. An orthologous gene was also detected in cynomolgus monkeys originating from four different geographical locations, but was absent in two African monkey species. Expression analysis in pig-tailed macaques revealed that the Mane-A*06 alleles encoded by this locus are transcribed at 10- to 20-fold lower levels than other MHC-A alleles (Mane-A*03 or Mane-A*10). Despite their conservation and high prevalence among Asian macaque species, the alleles of the Mane-A*06 family and, by extension their orthologues in rhesus and cynomolgus monkeys, may only modestly contribute to cellular immune responses in macaques because of their low level of expression.</abstract><cop>United States</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>17256149</pmid><doi>10.1007/s00251-007-0190-1</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Immunogenetics (New York), 2007-03, Vol.59 (3), p.211-223 |
| issn | 0093-7711 1432-1211 |
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| subjects | Alleles Amino Acid Sequence Animals Base Sequence Cynomolgus Evolution, Molecular Gene Duplication Gene Frequency Genes, MHC Class I Human immunodeficiency virus Immune system Immunization Introns Locus Macaca - genetics Macaca mulatta Macaca nemestrina MHC class I Molecular Sequence Data Monkeys & apes Phylogeny Polymorphism, Genetic Sequence Homology, Amino Acid Site specific primer-PCR (SSP-PCR) Swine |
| title | locus encoding an oligomorphic family of MHC-A alleles (Mane-A06/Mamu-A05) is present at high frequency in several macaque species |
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