Effects of thrombin on intracellular calcium and pH in human and murine platelets

The aim of this study was to compare the effect of thrombin (Thr) on cytosolic calcium [Ca 2 ] + i and intracellular pH [pH]i in human and murine platelets. Rich-platelet suspensions from both species were loaded with Fura-2 (2 w M) or BCECF (0.75 w M) by incubation with their respective acetoxymeth...

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Veröffentlicht in:	Platelets (Edinburgh) 2000-06, Vol.11 (4), p.233-240
1. Verfasser:	Salazar, L. Valencia, G. Sierra, J.L. Reyes, R. Paniagua, E. Melendez, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Blood Platelets - metabolism Calcium - metabolism Cytosol - metabolism Female Fluoresceins Fluorescent Dyes Fura-2 Humans Hydrogen-Ion Concentration - drug effects Image Processing, Computer-Assisted Intracellular Calcium Fura-2 Am Intracellular Ph Bcecf-AM Thrombin Magnesium - pharmacology Microscopy, Fluorescence Rats Rats, Wistar Species Specificity Thrombin - pharmacology
Online-Zugang:	Volltext
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