Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®)
In a highly mercury-burdened, small scale gold mining area in the Philippines, spontaneous urine samples were taken from 75 Hg intoxicated volunteers before (U1), and 2-3 hours after (U2) the oral application of 200 mg DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®). In the urine samples, the...
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| Veröffentlicht in: | Clinical toxicology (Philadelphia, Pa.) Pa.), 2007-01, Vol.45 (3), p.266-269 |
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| description | In a highly mercury-burdened, small scale gold mining area in the Philippines, spontaneous urine samples were taken from 75 Hg intoxicated volunteers before (U1), and 2-3 hours after (U2) the oral application of 200 mg DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®). In the urine samples, the concentrations of organic and inorganic bound mercury were determined separately by CV-AAS. In U1, median concentrations of 15.7 μg inorganic Hg g crea. and 2.2 μg organic Hg g crea. were found. In U2, these values increased to 262 for inorganic Hg and 14.5 for organic Hg. Maximum concentrations (μg g crea.) as high as 7,593 for inorganic Hg and 2,011 for organic Hg were observed after DMPS. The mean (median) increasing factor (U2 U1) was 16.0 for inorganic Hg and 5.1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent. |
| doi_str_mv | 10.1080/15563650601072175 |
| format | Article |
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In the urine samples, the concentrations of organic and inorganic bound mercury were determined separately by CV-AAS. In U1, median concentrations of 15.7 μg inorganic Hg g crea. and 2.2 μg organic Hg g crea. were found. In U2, these values increased to 262 for inorganic Hg and 14.5 for organic Hg. Maximum concentrations (μg g crea.) as high as 7,593 for inorganic Hg and 2,011 for organic Hg were observed after DMPS. The mean (median) increasing factor (U2 U1) was 16.0 for inorganic Hg and 5.1 for organic Hg. There was a trend that females responded better to DMPS than males. 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Toxic occupational diseases ; Concentration ; Dimaval ; DMPS ; Gold ; Humans ; Kidney - drug effects ; Kidney - metabolism ; Medical sciences ; Mercury ; Mercury - classification ; Mercury - urine ; Mercury Poisoning - drug therapy ; Mercury Poisoning - urine ; Metals and various inorganic compounds ; Methyl-mercury ; Methylmercury Compounds - poisoning ; Mining ; Occupational Diseases - drug therapy ; Occupational Diseases - urine ; Organo-mercury ; Speciation ; Spectrophotometry, Atomic - methods ; Toxicology ; Unithiol - administration & dosage ; Unithiol - pharmacology ; Urine</subject><ispartof>Clinical toxicology (Philadelphia, Pa.), 2007-01, Vol.45 (3), p.266-269</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-441ab1d49eebd50eba135aacd96e20ce8b5e3effd6a9d60b03bc2b90e116be9e3</citedby><cites>FETCH-LOGICAL-c496t-441ab1d49eebd50eba135aacd96e20ce8b5e3effd6a9d60b03bc2b90e116be9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/15563650601072175$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/15563650601072175$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18700749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17453878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drasch, Gustav</creatorcontrib><creatorcontrib>Boese-O'Reilly, Stephan</creatorcontrib><creatorcontrib>Illig, Sven</creatorcontrib><title>Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®)</title><title>Clinical toxicology (Philadelphia, Pa.)</title><addtitle>Clin Toxicol (Phila)</addtitle><description>In a highly mercury-burdened, small scale gold mining area in the Philippines, spontaneous urine samples were taken from 75 Hg intoxicated volunteers before (U1), and 2-3 hours after (U2) the oral application of 200 mg DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®). In the urine samples, the concentrations of organic and inorganic bound mercury were determined separately by CV-AAS. In U1, median concentrations of 15.7 μg inorganic Hg g crea. and 2.2 μg organic Hg g crea. were found. In U2, these values increased to 262 for inorganic Hg and 14.5 for organic Hg. Maximum concentrations (μg g crea.) as high as 7,593 for inorganic Hg and 2,011 for organic Hg were observed after DMPS. The mean (median) increasing factor (U2 U1) was 16.0 for inorganic Hg and 5.1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent.</description><subject>2,3-Dimercapto-1-propanesulfonic acid</subject><subject>Administration, Oral</subject><subject>Antidotes - administration & dosage</subject><subject>Antidotes - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Concentration</subject><subject>Dimaval</subject><subject>DMPS</subject><subject>Gold</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Medical sciences</subject><subject>Mercury</subject><subject>Mercury - classification</subject><subject>Mercury - urine</subject><subject>Mercury Poisoning - drug therapy</subject><subject>Mercury Poisoning - urine</subject><subject>Metals and various inorganic compounds</subject><subject>Methyl-mercury</subject><subject>Methylmercury Compounds - poisoning</subject><subject>Mining</subject><subject>Occupational Diseases - drug therapy</subject><subject>Occupational Diseases - urine</subject><subject>Organo-mercury</subject><subject>Speciation</subject><subject>Spectrophotometry, Atomic - methods</subject><subject>Toxicology</subject><subject>Unithiol - administration & dosage</subject><subject>Unithiol - pharmacology</subject><subject>Urine</subject><issn>0731-3810</issn><issn>1556-3650</issn><issn>1097-9875</issn><issn>1556-9519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt2K1TAUhYMoznH0AbyR3igKU905aZIWvZEZfwZGFNTrspPuejqmTSdp1T6Ar-ND-GTmcM4wiDBeBVa-tVk7K4zd5_CUQwnPuJRKKAkKOOg11_IGW3GodF6VWt5kK9CC56LkcMDuxHgOAEJIdZsdcF1IUepyxX6eDjYQRsp8mwUa0GX0IylT54et5MMXHHzeU7BzWDLr-9HPQxMz132lrKdp45bLS7NkJ-8-fMwer49EftJtZRwnn_N8DH7EgeLsWj90NkPbNUdZQvAbut-_ntxlt1p0ke7tz0P2-fWrT8dv87P3b06PX57ltqjUlBcFR8OboiIyjQQyyIVEtE2laA2WSiNJUNs2CqtGgQFh7NpUQJwrQxWJQ_ZoNzcFupgpTnXfRUvOpXB-jvUa0sNozf8L8koVUIBMIN-BNvgYA7X1GNJaYak51NuS6n9KSp4H--Gz6am5cuxbScDDPYDRomsDDraLV1ypIQWtEvdix3VD60OP331wTT3h4ny4NInrcjz_y74hdNPGYqD63M8h_YV4zRZ_AB01wWc</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Drasch, Gustav</creator><creator>Boese-O'Reilly, Stephan</creator><creator>Illig, Sven</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7ST</scope><scope>SOI</scope></search><sort><creationdate>20070101</creationdate><title>Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®)</title><author>Drasch, Gustav ; Boese-O'Reilly, Stephan ; Illig, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-441ab1d49eebd50eba135aacd96e20ce8b5e3effd6a9d60b03bc2b90e116be9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>2,3-Dimercapto-1-propanesulfonic acid</topic><topic>Administration, Oral</topic><topic>Antidotes - administration & dosage</topic><topic>Antidotes - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Concentration</topic><topic>Dimaval</topic><topic>DMPS</topic><topic>Gold</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Medical sciences</topic><topic>Mercury</topic><topic>Mercury - classification</topic><topic>Mercury - urine</topic><topic>Mercury Poisoning - drug therapy</topic><topic>Mercury Poisoning - urine</topic><topic>Metals and various inorganic compounds</topic><topic>Methyl-mercury</topic><topic>Methylmercury Compounds - poisoning</topic><topic>Mining</topic><topic>Occupational Diseases - drug therapy</topic><topic>Occupational Diseases - urine</topic><topic>Organo-mercury</topic><topic>Speciation</topic><topic>Spectrophotometry, Atomic - methods</topic><topic>Toxicology</topic><topic>Unithiol - administration & dosage</topic><topic>Unithiol - pharmacology</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drasch, Gustav</creatorcontrib><creatorcontrib>Boese-O'Reilly, Stephan</creatorcontrib><creatorcontrib>Illig, Sven</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drasch, Gustav</au><au>Boese-O'Reilly, Stephan</au><au>Illig, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®)</atitle><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle><addtitle>Clin Toxicol (Phila)</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>45</volume><issue>3</issue><spage>266</spage><epage>269</epage><pages>266-269</pages><issn>0731-3810</issn><issn>1556-3650</issn><eissn>1097-9875</eissn><eissn>1556-9519</eissn><abstract>In a highly mercury-burdened, small scale gold mining area in the Philippines, spontaneous urine samples were taken from 75 Hg intoxicated volunteers before (U1), and 2-3 hours after (U2) the oral application of 200 mg DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®). In the urine samples, the concentrations of organic and inorganic bound mercury were determined separately by CV-AAS. In U1, median concentrations of 15.7 μg inorganic Hg g crea. and 2.2 μg organic Hg g crea. were found. In U2, these values increased to 262 for inorganic Hg and 14.5 for organic Hg. Maximum concentrations (μg g crea.) as high as 7,593 for inorganic Hg and 2,011 for organic Hg were observed after DMPS. The mean (median) increasing factor (U2 U1) was 16.0 for inorganic Hg and 5.1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>17453878</pmid><doi>10.1080/15563650601072175</doi><tpages>4</tpages></addata></record> |
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| subjects | 2,3-Dimercapto-1-propanesulfonic acid Administration, Oral Antidotes - administration & dosage Antidotes - pharmacology Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Concentration Dimaval DMPS Gold Humans Kidney - drug effects Kidney - metabolism Medical sciences Mercury Mercury - classification Mercury - urine Mercury Poisoning - drug therapy Mercury Poisoning - urine Metals and various inorganic compounds Methyl-mercury Methylmercury Compounds - poisoning Mining Occupational Diseases - drug therapy Occupational Diseases - urine Organo-mercury Speciation Spectrophotometry, Atomic - methods Toxicology Unithiol - administration & dosage Unithiol - pharmacology Urine |
| title | Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval®) |
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