Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique

A modified w/o/w emulsion solvent evaporation technique was adopted to prepare human Chorionic Gonadotropin (hCG)-loaded polylactide (PLA) or poly(lactide-co-glycolide) (PLGA) microspheres. The effects of preparative parameters, such as stirring rate, polymer MW and concentration, and the compositio...

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Veröffentlicht in:	Journal of microencapsulation 2001, Vol.18 (2), p.247-260
Hauptverfasser:	ZHU, K. J, JIANG, H. L, DU, X. Y, WANG, J, XU, W. X, LIU, S. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - chemistry Animals Biodegradable Microspheres Emulsion-SOLVENT Evaporation Technique Single-SHOT Vaccine Antifertility Biological and medical sciences Chemistry, Pharmaceutical Chorionic Gonadotropin - administration & dosage Chorionic Gonadotropin - chemistry Chorionic Gonadotropin - immunology Emulsions Female General pharmacology Glycerol - chemistry Humans Immunization Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Kinetics Lactic Acid - administration & dosage Lactic Acid - chemistry Medical sciences Mice Microspheres Oils - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - administration & dosage Polyesters - chemistry Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Polymers - administration & dosage Polymers - chemistry Rats Solvents Volatilization Water - chemistry
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