Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy
We described the cerebral thrombotic complications developed in 2 adolescent patients treated with L-asparaginase-containing regimens. For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the...
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| Veröffentlicht in: | Leukemia & lymphoma 2005-05, Vol.46 (5), p.729-735 |
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| container_title | Leukemia & lymphoma |
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| creator | Imamura, Toshihiko Morimoto, Akira Kato, Ryuichi Izumi, Moriatu Murakami, Aki Matuo, Satoshi Kiyosawa, Nobuyuki Kano, Gen Yoshioka, Hiroshi Sugimoto, Tohru Imashuku, Shinsaku |
| description | We described the cerebral thrombotic complications developed in 2 adolescent patients treated with L-asparaginase-containing regimens. For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the 2 L-asparaginase-containing regimens; 11 were treated with VLP1 and the remaining 8 were treated with the VLAD protocol. The data indicated that low coagulation factors in association with increased plasma D-dimer levels during or post-L-asparaginase administration combined with fresh frozen plasma infusion might have activated coagulation processes in these patients. Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration. |
| doi_str_mv | 10.1080/10428190500052206 |
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For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the 2 L-asparaginase-containing regimens; 11 were treated with VLP1 and the remaining 8 were treated with the VLAD protocol. The data indicated that low coagulation factors in association with increased plasma D-dimer levels during or post-L-asparaginase administration combined with fresh frozen plasma infusion might have activated coagulation processes in these patients. Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.1080/10428190500052206</identifier><identifier>PMID: 16019511</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Antithrombin III - administration & dosage ; Asparaginase - administration & dosage ; Asparaginase - adverse effects ; cerebral thrombosis ; Child ; Child, Preschool ; D-dimer ; Female ; Fibrin Fibrinogen Degradation Products - biosynthesis ; fresh frozen plasma ; Humans ; Infant ; Intracranial Thrombosis - blood ; Intracranial Thrombosis - chemically induced ; L-asparaginase ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - drug therapy ; Male ; Plasma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Retrospective Studies ; Risk Factors</subject><ispartof>Leukemia & lymphoma, 2005-05, Vol.46 (5), p.729-735</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-1ad32c2569e049f1dfa80724a6dcc95eca6f92d1453382cf2a5d48dcd04ed75a3</citedby><cites>FETCH-LOGICAL-c435t-1ad32c2569e049f1dfa80724a6dcc95eca6f92d1453382cf2a5d48dcd04ed75a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10428190500052206$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10428190500052206$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16019511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imamura, Toshihiko</creatorcontrib><creatorcontrib>Morimoto, Akira</creatorcontrib><creatorcontrib>Kato, Ryuichi</creatorcontrib><creatorcontrib>Izumi, Moriatu</creatorcontrib><creatorcontrib>Murakami, Aki</creatorcontrib><creatorcontrib>Matuo, Satoshi</creatorcontrib><creatorcontrib>Kiyosawa, Nobuyuki</creatorcontrib><creatorcontrib>Kano, Gen</creatorcontrib><creatorcontrib>Yoshioka, Hiroshi</creatorcontrib><creatorcontrib>Sugimoto, Tohru</creatorcontrib><creatorcontrib>Imashuku, Shinsaku</creatorcontrib><title>Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>We described the cerebral thrombotic complications developed in 2 adolescent patients treated with L-asparaginase-containing regimens. For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the 2 L-asparaginase-containing regimens; 11 were treated with VLP1 and the remaining 8 were treated with the VLAD protocol. The data indicated that low coagulation factors in association with increased plasma D-dimer levels during or post-L-asparaginase administration combined with fresh frozen plasma infusion might have activated coagulation processes in these patients. Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Antithrombin III - administration & dosage</subject><subject>Asparaginase - administration & dosage</subject><subject>Asparaginase - adverse effects</subject><subject>cerebral thrombosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>D-dimer</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - biosynthesis</subject><subject>fresh frozen plasma</subject><subject>Humans</subject><subject>Infant</subject><subject>Intracranial Thrombosis - blood</subject><subject>Intracranial Thrombosis - chemically induced</subject><subject>L-asparaginase</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Male</subject><subject>Plasma</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhhtR3A_9AV4kJ2_tJumkp4NeZFBXGPCi51CTVG9nzUebpFnm4m_fHmZARNhTCvK8L1VP07xh9D2jA71hVPCBKSoppZJz2j9rLhnlquWCds-Ps-DtCoiL5qqU-yOlev6yuWA9ZUoydtn82WLGfQZP6pRT2KfqDDEpzN4ZqC7FQlwkYJPHYjBW4nH5hcHBjT-EeUoByLxy608hNSNUtOTB1YnsWigzZLhzEQq2JsUKLrp4R8yEIdUJM8yHV82LEXzB1-f3uvn55fOP7W27-_712_bTrjWik7VlYDtuuOwVUqFGZkcY6IYL6K0xSqKBflTcMiG7buBm5CCtGKyxVKDdSOium3en3jmn3wuWqoNb7_EeIqalaKb6bqMEW0F2Ak1OpWQc9ZxdgHzQjOqjdP2f9DXz9ly-7APav4mz5RX4eAJcHFMO8JCyt7rCwac8ZojGFd091f_hn_iE4OtkIKO-T0uOq7gntnsELC2lhA</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Imamura, Toshihiko</creator><creator>Morimoto, Akira</creator><creator>Kato, Ryuichi</creator><creator>Izumi, Moriatu</creator><creator>Murakami, Aki</creator><creator>Matuo, Satoshi</creator><creator>Kiyosawa, Nobuyuki</creator><creator>Kano, Gen</creator><creator>Yoshioka, Hiroshi</creator><creator>Sugimoto, Tohru</creator><creator>Imashuku, Shinsaku</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>200505</creationdate><title>Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy</title><author>Imamura, Toshihiko ; Morimoto, Akira ; Kato, Ryuichi ; Izumi, Moriatu ; Murakami, Aki ; Matuo, Satoshi ; Kiyosawa, Nobuyuki ; Kano, Gen ; Yoshioka, Hiroshi ; Sugimoto, Tohru ; Imashuku, Shinsaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-1ad32c2569e049f1dfa80724a6dcc95eca6f92d1453382cf2a5d48dcd04ed75a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Antithrombin III - administration & dosage</topic><topic>Asparaginase - administration & dosage</topic><topic>Asparaginase - adverse effects</topic><topic>cerebral thrombosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>D-dimer</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - biosynthesis</topic><topic>fresh frozen plasma</topic><topic>Humans</topic><topic>Infant</topic><topic>Intracranial Thrombosis - blood</topic><topic>Intracranial Thrombosis - chemically induced</topic><topic>L-asparaginase</topic><topic>Lymphoma, Non-Hodgkin - blood</topic><topic>Lymphoma, Non-Hodgkin - drug therapy</topic><topic>Male</topic><topic>Plasma</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imamura, Toshihiko</creatorcontrib><creatorcontrib>Morimoto, Akira</creatorcontrib><creatorcontrib>Kato, Ryuichi</creatorcontrib><creatorcontrib>Izumi, Moriatu</creatorcontrib><creatorcontrib>Murakami, Aki</creatorcontrib><creatorcontrib>Matuo, Satoshi</creatorcontrib><creatorcontrib>Kiyosawa, Nobuyuki</creatorcontrib><creatorcontrib>Kano, Gen</creatorcontrib><creatorcontrib>Yoshioka, Hiroshi</creatorcontrib><creatorcontrib>Sugimoto, Tohru</creatorcontrib><creatorcontrib>Imashuku, Shinsaku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imamura, Toshihiko</au><au>Morimoto, Akira</au><au>Kato, Ryuichi</au><au>Izumi, Moriatu</au><au>Murakami, Aki</au><au>Matuo, Satoshi</au><au>Kiyosawa, Nobuyuki</au><au>Kano, Gen</au><au>Yoshioka, Hiroshi</au><au>Sugimoto, Tohru</au><au>Imashuku, Shinsaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>2005-05</date><risdate>2005</risdate><volume>46</volume><issue>5</issue><spage>729</spage><epage>735</epage><pages>729-735</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>We described the cerebral thrombotic complications developed in 2 adolescent patients treated with L-asparaginase-containing regimens. For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the 2 L-asparaginase-containing regimens; 11 were treated with VLP1 and the remaining 8 were treated with the VLAD protocol. The data indicated that low coagulation factors in association with increased plasma D-dimer levels during or post-L-asparaginase administration combined with fresh frozen plasma infusion might have activated coagulation processes in these patients. Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>16019511</pmid><doi>10.1080/10428190500052206</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute lymphoblastic leukemia Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antithrombin III - administration & dosage Asparaginase - administration & dosage Asparaginase - adverse effects cerebral thrombosis Child Child, Preschool D-dimer Female Fibrin Fibrinogen Degradation Products - biosynthesis fresh frozen plasma Humans Infant Intracranial Thrombosis - blood Intracranial Thrombosis - chemically induced L-asparaginase Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - drug therapy Male Plasma Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Retrospective Studies Risk Factors |
| title | Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy |
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