Histiocytosis following T-acute lymphoblastic leukemia: A BFM study
The coincidence of T-cell acute lymphoblastic leukemia (T-ALL) and histiocytic disorders, including hemophagocytic lymphohistiocytosis (T-ALL HLH) and Langerhans cell histiocytosis (T-ALL LCH), is very seldom and is usually associated with a dismal prognosis. Retrospective statistical analysis of al...
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| Veröffentlicht in: | Leukemia & lymphoma 2005-12, Vol.46 (12), p.1735-1741 |
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| creator | Trebo, Monika M. Attarbaschi, Andishe Mann, Georg Minkov, Milen Kornmüller, Rosi Gadner, Helmut |
| description | The coincidence of T-cell acute lymphoblastic leukemia (T-ALL) and histiocytic disorders, including hemophagocytic lymphohistiocytosis (T-ALL HLH) and Langerhans cell histiocytosis (T-ALL LCH), is very seldom and is usually associated with a dismal prognosis. Retrospective statistical analysis of all T-ALL patients, who have been registered in the BFM-ALL trials from 1981 - 2001 and who have subsequently developed a LCH HLH, in order to identify any common risk factors pre-disposing to the synchronous occurrence of both disorders. Six out of 971 T-ALL patients had either HLH or LCH ( 0.03% of treated T-ALL year). The mean age at diagnosis of T-ALL HLH LCH was significantly lower than in the remaining T-ALL group (4.05 ± 0.59 vs 8.82 ± 0.14 years; p = 0.000). The mean initial leukocyte count was higher than in the non-HLH LCH group (270 700 ± 60 677 μl−1 vs 134 141 ± 5663 μl−1; p = 0.074). No hemophagocytosis was seen in the initial bone marrow (BM) smears. Five of 6 patients obtained a good prednisone response (GPR) at day 8 in peripheral blood with |
| doi_str_mv | 10.1080/10428190500160017 |
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Retrospective statistical analysis of all T-ALL patients, who have been registered in the BFM-ALL trials from 1981 - 2001 and who have subsequently developed a LCH HLH, in order to identify any common risk factors pre-disposing to the synchronous occurrence of both disorders. Six out of 971 T-ALL patients had either HLH or LCH ( 0.03% of treated T-ALL year). The mean age at diagnosis of T-ALL HLH LCH was significantly lower than in the remaining T-ALL group (4.05 ± 0.59 vs 8.82 ± 0.14 years; p = 0.000). The mean initial leukocyte count was higher than in the non-HLH LCH group (270 700 ± 60 677 μl−1 vs 134 141 ± 5663 μl−1; p = 0.074). No hemophagocytosis was seen in the initial bone marrow (BM) smears. Five of 6 patients obtained a good prednisone response (GPR) at day 8 in peripheral blood with <5% blasts at day 15 in BM and all cases were in complete remission (CR) at day 33. The mean time until development of the histiocytosis was 17.95 months (range 2.5 - 33 months). Four patients developed a HLH and 2 a LCH. All patients with HLH showed a multi-organ involvement, while the LCH patients had only local disease. Only the LCH patients survived, while all patients with HLH died. The authors recommend a close follow-up for at least 3 years after diagnosis in younger T-ALL patients with high initial leukocyte count.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.1080/10428190500160017</identifier><identifier>PMID: 16263575</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Acute lymphoblastic leukemia ; bone marrow biopsy ; Bone Marrow Cells - pathology ; chemotherapy ; Child, Preschool ; Clinical Trials as Topic ; Female ; hemophagocytic lymphohistiocytosis ; Histiocytosis - etiology ; Histiocytosis, Langerhans-Cell - pathology ; Humans ; Langerhans cell histiocytosis ; Leukemia-Lymphoma, Adult T-Cell - pathology ; Male ; Retrospective Studies</subject><ispartof>Leukemia & lymphoma, 2005-12, Vol.46 (12), p.1735-1741</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-c3d630b8cce07f639e4ef8d371addfbb549861b9170cd7941f248d17c1dcf3963</citedby><cites>FETCH-LOGICAL-c435t-c3d630b8cce07f639e4ef8d371addfbb549861b9170cd7941f248d17c1dcf3963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10428190500160017$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10428190500160017$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16263575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trebo, Monika M.</creatorcontrib><creatorcontrib>Attarbaschi, Andishe</creatorcontrib><creatorcontrib>Mann, Georg</creatorcontrib><creatorcontrib>Minkov, Milen</creatorcontrib><creatorcontrib>Kornmüller, Rosi</creatorcontrib><creatorcontrib>Gadner, Helmut</creatorcontrib><title>Histiocytosis following T-acute lymphoblastic leukemia: A BFM study</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>The coincidence of T-cell acute lymphoblastic leukemia (T-ALL) and histiocytic disorders, including hemophagocytic lymphohistiocytosis (T-ALL HLH) and Langerhans cell histiocytosis (T-ALL LCH), is very seldom and is usually associated with a dismal prognosis. Retrospective statistical analysis of all T-ALL patients, who have been registered in the BFM-ALL trials from 1981 - 2001 and who have subsequently developed a LCH HLH, in order to identify any common risk factors pre-disposing to the synchronous occurrence of both disorders. Six out of 971 T-ALL patients had either HLH or LCH ( 0.03% of treated T-ALL year). The mean age at diagnosis of T-ALL HLH LCH was significantly lower than in the remaining T-ALL group (4.05 ± 0.59 vs 8.82 ± 0.14 years; p = 0.000). The mean initial leukocyte count was higher than in the non-HLH LCH group (270 700 ± 60 677 μl−1 vs 134 141 ± 5663 μl−1; p = 0.074). No hemophagocytosis was seen in the initial bone marrow (BM) smears. Five of 6 patients obtained a good prednisone response (GPR) at day 8 in peripheral blood with <5% blasts at day 15 in BM and all cases were in complete remission (CR) at day 33. The mean time until development of the histiocytosis was 17.95 months (range 2.5 - 33 months). Four patients developed a HLH and 2 a LCH. All patients with HLH showed a multi-organ involvement, while the LCH patients had only local disease. Only the LCH patients survived, while all patients with HLH died. The authors recommend a close follow-up for at least 3 years after diagnosis in younger T-ALL patients with high initial leukocyte count.</description><subject>Acute lymphoblastic leukemia</subject><subject>bone marrow biopsy</subject><subject>Bone Marrow Cells - pathology</subject><subject>chemotherapy</subject><subject>Child, Preschool</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>hemophagocytic lymphohistiocytosis</subject><subject>Histiocytosis - etiology</subject><subject>Histiocytosis, Langerhans-Cell - pathology</subject><subject>Humans</subject><subject>Langerhans cell histiocytosis</subject><subject>Leukemia-Lymphoma, Adult T-Cell - pathology</subject><subject>Male</subject><subject>Retrospective Studies</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L5TAUhoOM-P0D3EhXs6ueNGnSzMzGufgFihtdhzQf3mja3ElapP9-KveCiKCLwzmL5305PAgdYzjF0MAZBlo1WEANgNk8fAvtYahEWVEgP95uWpUzQHfRfs7PAFALVu2gXcwqRmpe76HFtc-Dj3oaYva5cDGE-Or7p-KhVHocbBGmbrWMbVAzpotgxxfbefWrOC_-Xt4VeRjNdIi2nQrZHm32AXq8vHhYXJe391c3i_PbUlNSD6UmhhFoG60tcMeIsNS6xhCOlTGubWsqGoZbgTlowwXFrqKNwVxjox0RjBygn-veVYr_RpsH2fmsbQiqt3HMkjW85g1U34J4LuNUiBnEa1CnmHOyTq6S71SaJAb5plh-UjxnTjblY9tZ857YOJ2BP2vA9y6mTr3GFIwc1BRickn12mdJvur__SG-tCoMS62Slc9xTP1s-Ivv_gMpJpr8</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Trebo, Monika M.</creator><creator>Attarbaschi, Andishe</creator><creator>Mann, Georg</creator><creator>Minkov, Milen</creator><creator>Kornmüller, Rosi</creator><creator>Gadner, Helmut</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Histiocytosis following T-acute lymphoblastic leukemia: A BFM study</title><author>Trebo, Monika M. ; Attarbaschi, Andishe ; Mann, Georg ; Minkov, Milen ; Kornmüller, Rosi ; Gadner, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-c3d630b8cce07f639e4ef8d371addfbb549861b9170cd7941f248d17c1dcf3963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>bone marrow biopsy</topic><topic>Bone Marrow Cells - pathology</topic><topic>chemotherapy</topic><topic>Child, Preschool</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>hemophagocytic lymphohistiocytosis</topic><topic>Histiocytosis - etiology</topic><topic>Histiocytosis, Langerhans-Cell - pathology</topic><topic>Humans</topic><topic>Langerhans cell histiocytosis</topic><topic>Leukemia-Lymphoma, Adult T-Cell - pathology</topic><topic>Male</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trebo, Monika M.</creatorcontrib><creatorcontrib>Attarbaschi, Andishe</creatorcontrib><creatorcontrib>Mann, Georg</creatorcontrib><creatorcontrib>Minkov, Milen</creatorcontrib><creatorcontrib>Kornmüller, Rosi</creatorcontrib><creatorcontrib>Gadner, Helmut</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trebo, Monika M.</au><au>Attarbaschi, Andishe</au><au>Mann, Georg</au><au>Minkov, Milen</au><au>Kornmüller, Rosi</au><au>Gadner, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histiocytosis following T-acute lymphoblastic leukemia: A BFM study</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>46</volume><issue>12</issue><spage>1735</spage><epage>1741</epage><pages>1735-1741</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>The coincidence of T-cell acute lymphoblastic leukemia (T-ALL) and histiocytic disorders, including hemophagocytic lymphohistiocytosis (T-ALL HLH) and Langerhans cell histiocytosis (T-ALL LCH), is very seldom and is usually associated with a dismal prognosis. Retrospective statistical analysis of all T-ALL patients, who have been registered in the BFM-ALL trials from 1981 - 2001 and who have subsequently developed a LCH HLH, in order to identify any common risk factors pre-disposing to the synchronous occurrence of both disorders. Six out of 971 T-ALL patients had either HLH or LCH ( 0.03% of treated T-ALL year). The mean age at diagnosis of T-ALL HLH LCH was significantly lower than in the remaining T-ALL group (4.05 ± 0.59 vs 8.82 ± 0.14 years; p = 0.000). The mean initial leukocyte count was higher than in the non-HLH LCH group (270 700 ± 60 677 μl−1 vs 134 141 ± 5663 μl−1; p = 0.074). No hemophagocytosis was seen in the initial bone marrow (BM) smears. Five of 6 patients obtained a good prednisone response (GPR) at day 8 in peripheral blood with <5% blasts at day 15 in BM and all cases were in complete remission (CR) at day 33. The mean time until development of the histiocytosis was 17.95 months (range 2.5 - 33 months). Four patients developed a HLH and 2 a LCH. All patients with HLH showed a multi-organ involvement, while the LCH patients had only local disease. Only the LCH patients survived, while all patients with HLH died. The authors recommend a close follow-up for at least 3 years after diagnosis in younger T-ALL patients with high initial leukocyte count.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>16263575</pmid><doi>10.1080/10428190500160017</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute lymphoblastic leukemia bone marrow biopsy Bone Marrow Cells - pathology chemotherapy Child, Preschool Clinical Trials as Topic Female hemophagocytic lymphohistiocytosis Histiocytosis - etiology Histiocytosis, Langerhans-Cell - pathology Humans Langerhans cell histiocytosis Leukemia-Lymphoma, Adult T-Cell - pathology Male Retrospective Studies |
| title | Histiocytosis following T-acute lymphoblastic leukemia: A BFM study |
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