Synthesis and biological activity of 9-dialkylaminoethyl-2-oxy(dioxy)-phenylimidazo[1,2-a]benzimidazole s

Synthesis and biological activity of 9-dialkylaminoethyl-2-oxy(dioxy)-phenylimidazo[1,2-a]benzimidazole s

A series of 9-dialkylaminoethyl-2-oxy(dioxy)phenylimidazo[1,2-a]benzimidazoles have been synthesized and their pharmacological properties have been studied. Some compounds exhibit pronounced antioxidant activity, as confirmed on experimental pathological models in animals. The tests also revealed me...

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Veröffentlicht in:Pharmaceutical chemistry journal 2006-10, Vol.40 (10), p.521-529
Hauptverfasser: Anisimova, V A, Spasov, A A, Kosolapov, V A, Chernikov, M V, Stukovina, AYu, El'tsova, LV, Larionov, N P, Libinzon, R E, Vatolkina, O E
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container_end_page 529
container_issue 10
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container_title Pharmaceutical chemistry journal
container_volume 40
creator Anisimova, V A
Spasov, A A
Kosolapov, V A
Chernikov, M V
Stukovina, AYu
El'tsova, LV
Larionov, N P
Libinzon, R E
Vatolkina, O E
description A series of 9-dialkylaminoethyl-2-oxy(dioxy)phenylimidazo[1,2-a]benzimidazoles have been synthesized and their pharmacological properties have been studied. Some compounds exhibit pronounced antioxidant activity, as confirmed on experimental pathological models in animals. The tests also revealed membranotropic, spasmolytic, antiaggregant, hemorheological, anticalmodulin, antiulcer, and hypotensive activity, and the properties of serotonin 5-HT sub(2) and 5-HT sub(3) receptor antagonists. The results confirm good prospects for the synthesis and screening of biologically active substances among benzimidazoles of this series.
doi_str_mv 10.1007/s11094-006-0185-5
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title Synthesis and biological activity of 9-dialkylaminoethyl-2-oxy(dioxy)-phenylimidazo[1,2-a]benzimidazole s
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