Immunomodulatory Effects of Tyrosine Kinase Inhibitor In Vitro and In Vivo Study

•TKIs suppress the production of proinflammatory cytokines in vitro, including IL-17.•TKIs reduce the frequency of total Tregs in vitro but preserve naive subsets.•B and NK cells are impaired by TKIs in vitro, whereas T cells are preserved.•Comparable results were obtained in patients treated with n...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2018-02, Vol.24 (2), p.267-275
Hauptverfasser:	Marinelli Busilacchi, Elena, Costantini, Andrea, Viola, Nadia, Costantini, Benedetta, Olivieri, Jacopo, Butini, Luca, Mancini, Giorgia, Scortechini, Ilaria, Chiarucci, Martina, Poiani, Monica, Poloni, Antonella, Leoni, Pietro, Olivieri, Attilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Specimen Collection Cells, Cultured Chronic graft-versus-host disease (cGVHD) Cytokine production Cytokines - drug effects Humans Immunologic Factors - pharmacology Killer Cells, Natural - drug effects Lymphocyte subpopulations Protein Kinase Inhibitors - immunology Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Pyrimidines - pharmacology Pyrimidines - therapeutic use T regulatory cells T-Lymphocyte Subsets - drug effects T-Lymphocytes, Regulatory - drug effects Tyrosine kinase inhibitors (TKIs)
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