Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway

Obesity based on insulin resistance is a state of chronic oxidative stress and inflammation that are highly regulated through nuclear factor Erythroid 2-related factor 2 (NrF2) pathway. 70 male Wistar rats were randomized into two models. The prophylactic model was 10weeks and rats were grouped into...

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Veröffentlicht in:	Life sciences (1973) 2018-01, Vol.193, p.159-170
Hauptverfasser:	Abo El-Magd, Nada F., El-Mesery, Mohamed, El-Karef, Amro, El-Shishtawy, Mamdouh M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipose tissue Adipose Tissue - metabolism Adipose tissues Animal models Animals Antioxidants Diet Diet, High-Fat Gene expression Gluconeogenic enzymes Glycyrrhizic Acid - metabolism Glycyrrhizic Acid - pharmacology Glycyrrhizic Acid - therapeutic use Glycyrrhizin High fat diet Inflammation - pathology Insulin Insulin - metabolism Insulin receptor Insulin resistance Insulin Resistance - physiology Liver Liver - metabolism Male Malondialdehyde NF-E2-Related Factor 2 - metabolism Nuclear factor erythroid-2 related factor-2 Nuclear transport Obesity Obesity - metabolism Obesity - prevention & control Oxidation resistance Oxidative stress Oxidative Stress - physiology Oxygen Prophylaxis Rats Rats, Wistar Receptor, Insulin - metabolism Translocation
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